2210-25-5Relevant articles and documents
A ritter-type reaction over H-ZSM-5: Synthesis of N-isopropylacrylamide from acrylonitrile and isopropyl alcohol
Chen, Xin,Okuhara, Toshio
, p. 194 - 201 (2002)
Catalytic synthesis of N-isopropylacrylamide from acrylonitrile and isopropyl alcohol has been studied using a variety of solid acids in a solid-liquid reaction system at 423 K. Among typical solid and liquid acids, H-ZSM-5 exhibited an exceptionally high catalytic activity. The activity (per gram) of H-ZSM-5 increased as the Al-content (100Al/(Si + Al)%) increased and then decreased through a maximum at an Al content of 2.63%. The specific activity per one acid site, which was estimated from the initial rate and the acid amount, increased greatly as the Al content decreased, which resembles those of the hydrophobicity and the acid strength. The superiority of H-ZSM-5 activity over other strong and hydrophobic solid acids suggests the importance of the unique pore structure. While H-ZSM-5 deactivated severely during the reaction, the catalytic activities were mostly recovered by calcination at 773 K in air. IR spectroscopy and adsorption measurements revealed that the deactivation of H-ZSM-5 was mainly caused by the formation of a polymer of acrylonitrile on the catalyst surface blocking the micropores, but not limiting desorption of the product from the micropores.
Iridium-Catalyzed Asymmetric Hydroalkenylation of Norbornene Derivatives
Sun, Xin,Bai, Xiao-Yan,Li, An-Zhen,Li, Bi-Jie
supporting information, p. 2182 - 2187 (2021/03/01)
Transition-metal-catalyzed asymmetric hydroalkenylation of alkenes provides an atom-economical method to build molecular complexity from easily available materials. Herein we report an iridium-catalyzed asymmetric hydroalkenylation of unconjugated alkenes with acrylamides and acrylates. The catalytic hydroalkenylation of norbornene derivatives occurred to form products with allylic stereocenters with high chemo-, regio-, and stereoselectivities. DFT calculations revealed that the migratory insertion is irreversible and the enantiodetermination step.
Synthesis process of N-isopropylacrylamide
-
Paragraph 0023, (2018/04/01)
The invention relates to a synthesis process of N-isopropylacrylamide, and belongs to the technical field of new materials. According to the process, acrylonitrile and isopropanol have an alkylation reaction under the catalyzing of tetra-n-butylammonium chloride and sulphuric acid to prepare the N-isopropylacrylamide, an organic layer is separated after the N-isopropylacrylamide is neutralized through ammonium hydroxide, then the N-isopropylacrylamide is extracted through water, an extraction liquid is directly cooled and crystalized after being concentrated to obtain an N-isopropylacrylamide crystal, and the N-isopropylacrylamide crystal is dried in vacuum to obtain a product. The used raw materials are cheap and easy to get, the cost is low, the product purity is high, the yield is high, and the process flow is short. The synthesis process has a broad application prospect in the large-scale production of the N-isopropylacrylamide in a workshop.