221049-51-0

Basic information

• Product Name: 4H-1,4-Benzoxazine-4-carboxylic acid, 3-[(diphenoxyphosphinyl)oxy]-, 1,1-dimethylethyl ester
• CAS NO: 221049-51-0
• Molecular Formula: C25H24NO7P
• Molecular Weight: 481.442
• Mol File: 221049-51-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4H-1,4-Benzoxazine-4-carboxylic acid, 3-[(diphenoxyphosphinyl)oxy]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-1,4-Benzoxazine-4-carboxylic acid, 3-[(diphenoxyphosphinyl)oxy]-, 1,1-dimethylethyl ester(221049-51-0)
• EPA Substance Registry System: 4H-1,4-Benzoxazine-4-carboxylic acid, 3-[(diphenoxyphosphinyl)oxy]-, 1,1-dimethylethyl ester(221049-51-0)

Safety Data

• Hazardous Substances Data: 221049-51-0(Hazardous Substances Data)

Upstream product

• 5466-88-6 3,4-dihydro-3-oxo-2H-1,4-benzoxazine 
• 2524-64-3 chlorophosphoric acid diphenyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 221049-50-9 tert-butyl 3-oxo-3,4-dihydro-2H-1,4-benzoxazine-4-carboxylate 

Downstream Products

• 221049-57-6 4-(tert-butoxycarbonyl)-3-phenyl-4H-1,4-benzoxazine 

Relevant articles and documents

Synthesis of 3-substituted-4H-1,4-benzoxazines via palladium-catalysed coupling reactions

Here is described a high yield synthesis of 3-substituted 4H-1,4- benzoxazines via palladium-catalysed coupling reactions between organostannanes and a vinylphosphate obtained from a benzoxazin-3-one derivative.

Synthesis of 3-substituted and 2,3-disubstituted-4H-1,4-benzoxazines

Two new and efficient synthetic routes towards substituted 4H-1,4- benzoxazine derivatives were reported. The first one involves the synthesis in four steps of the 4-Boc-4H-1,4-benzoxazine and its regioselective substitution on C-3 following a lithiation-