22106-39-4

Basic information

• Product Name: 3-METHOXY-4-NITROACETOPHENONE
• Synonyms: 3'-METHOXY-4'-NITROACETOPHENONE;3-METHOXY-4-NITROACETOPHENONE;1-(3-METHOXY-4-NITROPHENYL)-1-ETHANONE;4-Acetyl-2-methoxynitrobenzene, 5-Acetyl-2-nitroanisole;1-(3-Methoxy-4-nitrophenyl)ethanone;4-Acetyl-2-methoxynitrobenzene, 5-Acetyl-2-nitroanisole, 1-(3-Methoxy-4-nitrophenyl)ethan-1-one;4-Acetyl-2-methoxynitrobenzene
• CAS NO: 22106-39-4
• Molecular Formula: C₉H₉NO₄
• Molecular Weight: 195.17
• Product Categories: Aromatic Acetophenones & Derivatives (substituted)
• Mol File: 22106-39-4.mol
• Article Data: 10

Chemical Properties

• Melting Point: 71-73°C
• Boiling Point: 321.642 °C at 760 mmHg
• Flash Point: 152.709 °C
• Appearance: /
• Density: 1.245 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.544
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-METHOXY-4-NITROACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHOXY-4-NITROACETOPHENONE(22106-39-4)
• EPA Substance Registry System: 3-METHOXY-4-NITROACETOPHENONE(22106-39-4)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 22106-39-4(Hazardous Substances Data)

Usage

General Description

3-Methoxy-4-nitroacetophenone is a chemical compound with the molecular formula C9H9NO4. It is an organic compound that belongs to the class of phenyl ketones. This yellow crystalline compound is commonly used in the synthesis of pharmaceuticals and agrochemicals. Its chemical structure consists of a phenyl ring with a methoxy group attached to the para position and a nitro group attached to the meta position. It is known to be a powerful and versatile building block in organic chemistry, as it can be used in the synthesis of a variety of complex molecules. 3-METHOXY-4-NITROACETOPHENONE has also demonstrated antibacterial and anti-inflammatory properties, making it a valuable tool in drug research and development.

InChI:InChI=1/C9H9NO4/c1-6(11)7-3-4-8(10(12)13)9(5-7)14-2/h3-5H,1-2H3

Upstream product

• 186581-53-3 diazomethane 
• 89942-63-2 1-(5-hydroxy-4-nitrophenyl)ethanone 
• 67579-92-4 3-methoxy-4-nitrobenzoic acid chloride 
• 105-53-3 diethyl malonate 
• 108-59-8 malonic acid dimethyl ester 
• 91-23-6 2-Nitroanisole 
• 38512-82-2 3-methoxy-4-nitrotoluene 
• 5081-36-7 3-methoxy-4-nitrobenzoic acid 

Downstream Products

• 607713-39-3 2-[1-(3-methoxy-4-nitrophenyl)ethylidene]malononitrile 
• 607713-40-6 2-amino-4-(3-methoxy-4-nitrophenyl)-3-thiophenecarbonitrile 
• 607713-42-8 5-(4-amino-3-methoxyphenyl)thieno[2,3-d]pyrimidin-4-amine 
• 13788-72-2 6-methoxy-4(1H)-quinolinone 
• 93023-15-5 <4-Nitro-3-methoxy-phenacyl>-malonsaeurediaethylester 
• 1365620-93-4 (E)-[1-(1,3-dihydro-1-hydroxy-2,1-benzoxaborol-6-yl)-3-(3-methoxy-4-nitrophenyl)]propenone 
• 22106-40-7 1-(4-amino-3-methoxyphenyl)ethan-1-one 
• 1197180-35-0 C₁₀H₉N₃O₃ 

Relevant articles and documents

Reactions of 1-(benzotriazol-1-yl)-1-phenoxyalkane and (benzotriazol-1- yl)ethoxyphenylmethane anions with nitroarenes: A new approach to alkyl and aryl p-nitroaryl ketones

p-Nitroaryl alkyl ketones and p-nitroaryl aryl ketones are prepared regioselectively by reactions of non-functionalized nitroarenes and benzotriazole stabilized carbanions.

Heterocyclic Compounds and Methods of Use

This disclosure provides compounds and methods of using those compounds to treat liver fibrosis, including liver fibrosis which is a precursor to, is concurrent with, is associated with, or is secondary to nonalcoholic steatohepatitis (NASH); elevated cholesterol levels, and insulin resistance.

HETEROCYCLIC COMPOUNDS AND METHODS OF USE

This disclosure provides compounds and methods of using those compounds to treat metabolic disorders and hyperproliferative disorders, including administration of the compounds in conjunction with hormone receptor antagonists. Compounds of the invention may also find use in treating cancer. Presented herein are novel compounds bearing a perhaloalkylsulfonamide moiety. Such compounds, in addition to being highly effective SREBP inhibitors, are also unexpectedly highly bioavailable in vivo. Heteroaromatic compounds bearing sulfonamide groups are prone to several ionic states, based on the inherent pKa values.