221060-78-2

Basic information

• Product Name: 2-bromo-N-(2-hydroxy-4-methoxyphenyl)-5-methyl-3-thiophenecarboxamide
• Synonyms: 2-bromo-N-(2-hydroxy-4-methoxyphenyl)-5-methyl-3-thiophenecarboxamide
• CAS NO: 221060-78-2
• Molecular Weight: 342.213
• Mol File: 221060-78-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-bromo-N-(2-hydroxy-4-methoxyphenyl)-5-methyl-3-thiophenecarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-N-(2-hydroxy-4-methoxyphenyl)-5-methyl-3-thiophenecarboxamide(221060-78-2)
• EPA Substance Registry System: 2-bromo-N-(2-hydroxy-4-methoxyphenyl)-5-methyl-3-thiophenecarboxamide(221060-78-2)

Safety Data

• Hazardous Substances Data: 221060-78-2(Hazardous Substances Data)

Upstream product

• 40925-70-0 2-amino-5-methoxyphenol 
• 221060-79-3 2-Bromo-5-methyl-3-thiophenecarbonyl chloride 
• 221061-14-9 2-bromo-5-methylthiophene-3-carboxylic acid 
• 19156-50-4 5-methyl-thiophene-3-carboxylic acid 
• 29421-92-9 4-bromo-2-methylthiophene 

Relevant articles and documents

Synthesis of thieno[2,3-b][1,5]benzoxazepine derivatives

A new series of 4-(4-methylpiperazin-1-yl)thieno[2,3-b][1,5]benzoxazepines 1a-k has been synthesized from 4-bromo-2-methylthiophene 6 or ethyl 2-amino-4,5-dimethyl-3-thiophencarboxylate 10. Preparation of the key intermediate thieno[2,3-b][1,5]benzoxazepine-4(5H)-ones 4a-i, 4k were carried out by treatment of 2-bromo-N-(2-hydroxyphenyl)-3-thiophencarboxamides 5a-i, 5k with potassium carbonate in DMSO. Compounds 1 are thienoanalogues of loxapine, a potent antipsychotic drug. Of these compounds, the neuroleptic activity of 2-methyl-4-(4-methylpiperazin-1-yl)thieno[2,3-b][1,5]benzoxazepine 1a (R1, R3=H, R2=CH3) demonstrated potent antipsychotic activity.