221087-65-6

Basic information

• Product Name: Pyridine, 2-(2,5-dimethyl-1H-pyrrol-1-yl)-6-[4-(phenylmethoxy)-1-naphthalenyl]-
• CAS NO: 221087-65-6
• Molecular Formula: C28H24N2O
• Molecular Weight: 404.511
• Mol File: 221087-65-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Pyridine, 2-(2,5-dimethyl-1H-pyrrol-1-yl)-6-[4-(phenylmethoxy)-1-naphthalenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 2-(2,5-dimethyl-1H-pyrrol-1-yl)-6-[4-(phenylmethoxy)-1-naphthalenyl]-(221087-65-6)
• EPA Substance Registry System: Pyridine, 2-(2,5-dimethyl-1H-pyrrol-1-yl)-6-[4-(phenylmethoxy)-1-naphthalenyl]-(221087-65-6)

Safety Data

• Hazardous Substances Data: 221087-65-6(Hazardous Substances Data)

Upstream product

• 138865-41-5 1-(benzyloxy)-4-bromonaphthalene 
• 571-57-3 4-bromo-1-naphthol 
• 90-15-3 α-naphthol 
• 183170-90-3 1-benzyloxynaphthalene-4-boronic acid 
• 198209-31-3 2-bromo6-(2,5-dimethyl-pyrrol-1-yl)-pyridine 

Relevant articles and documents

Structure-Activity Relationships of Potent, Selective Inhibitors of Neuronal Nitric Oxide Synthase Based on the 6-Phenyl-2-aminopyridine Structure

The synthesis and structure-activity relationships of a series of 6-phenyl-2-aminopyridines that potently and selectively inhibit the neuronal isoform of nitric oxide synthase (nNOS) are described. Compound 14bi from this series exhibits potent in vivo activity in harmaline-induced cGMP formation in rat cerebellum, a functional model of nNOS inhibition, and in the PCP-induced hypermotility model in the rat. These results suggest that 14bi may be a useful reagent for evaluating potential therapeutic applications of nNOS inhibitors in the central nervous system.