221093-45-4 Usage
Description
17beta-Estradiol-2,4,16,16,17-D5 is a stable-labeled internal standard used for 17beta-Estradiol testing or isotope dilution methods by GC/MS or LC/MS in endocrinology, clinical chemistry, or diagnostic purposes. Estradiol, the hormone it is related to, is prescribed under various trade names for the treatment of hypoestrogenism.
Uses
Used in Endocrinology and Clinical Chemistry:
17beta-Estradiol-2,4,16,16,17-D5 is used as an internal standard for accurate quantification of 17beta-Estradiol levels in biological samples, aiding in the diagnosis and monitoring of endocrine disorders and related health conditions.
Used in Diagnostic Purposes:
17beta-Estradiol-2,4,16,16,17-D5 serves as a reliable reference in diagnostic tests to ensure the precision and accuracy of 17beta-Estradiol measurements, which is crucial for assessing a patient's hormonal balance and diagnosing hypoestrogenism.
Used in Pharmaceutical Formulations:
17beta-Estradiol-2,4,16,16,17-D5 can be utilized in the development and quality control of pharmaceutical products containing Estradiol, ensuring the correct dosage and potency of the hormone in medications like Vagifem, Estring, Evamist, Elestrin, Estrace, and Estrogel.
Check Digit Verification of cas no
The CAS Registry Mumber 221093-45-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,1,0,9 and 3 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 221093-45:
(8*2)+(7*2)+(6*1)+(5*0)+(4*9)+(3*3)+(2*4)+(1*5)=94
94 % 10 = 4
So 221093-45-4 is a valid CAS Registry Number.
221093-45-4Relevant articles and documents
Microwave-assisted synthesis of deuterium labeled estrogen fatty acid esters
Kiuru, Paula S.,Waehaelae, Kristiina
, p. 54 - 60 (2007/10/03)
Deuterated analogs of estrogen fatty acid esters are needed as internal standards for isotope dilution GC/MS analyses. We have developed a rapid and efficient synthesis for 2,4,16,16-D4-estrone palmitate, stearate, oleate, linoleate, and linolenate and the corresponding 2,4,16,16,17α- D5-estradiol fatty acid 17-mono and 3,17-diesters using analogous fatty acid chlorides or fatty acid anhydrides and 4-(dimethylamino)pyridine under microwave irradiation. Chemoselective hydrolysis of fatty acid diesters was carried out by KOH in t-BuOH.
