221121-29-5

Basic information

• Product Name: 2-(3-Fluoro-phenyl)-1-imidazol-1-yl-ethanone
• Synonyms: 2-(3-Fluoro-phenyl)-1-imidazol-1-yl-ethanone
• CAS NO: 221121-29-5
• Molecular Weight: 204.204
• Mol File: 221121-29-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(3-Fluoro-phenyl)-1-imidazol-1-yl-ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-Fluoro-phenyl)-1-imidazol-1-yl-ethanone(221121-29-5)
• EPA Substance Registry System: 2-(3-Fluoro-phenyl)-1-imidazol-1-yl-ethanone(221121-29-5)

Safety Data

• Hazardous Substances Data: 221121-29-5(Hazardous Substances Data)

Upstream product

• 530-62-1 1,1'-carbonyldiimidazole 
• 331-25-9 (3-fluorophenyl)acetic acid 

Downstream Products

• 221121-53-5 6-(3-fluoro-benzyl)-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one 
• 221121-60-4 6-(3-fluoro-benzyl)-5-methyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one 
• 1091581-54-2 2-(3-fluorophenyl)-1-(1-pyrrolidinyl)ethanone 
• 1381886-77-6 N-(2-(3-fluorophenyl)ethyl)-7-azabicyclo[2.2.1]heptane 
• 1381886-86-7 N-(2-(3-fluorophenyl)ethyl)pyrrolidine 
• 221121-36-4 4-(3-fluorophenyl)-3-oxobutyric acid ethyl ester 

Relevant articles and documents

7-Azabicyclo[2.2.1]heptane as a scaffold for the development of selective sigma-2 (σ2) receptor ligands

A series of N-substituted 7-azabicyclo[2.2.1]heptanes (12-17 and 22-25) and similarly substituted pyrrolidines (32-36 and 41-44) were synthesized as sterically-reduced, achiral analogs of adamantane- and trishomocubane-derived σ ligands. In vitro competition binding assays against σ receptors revealed that arylalkyl N-substituents conferred selectivity for the σ2 subtype, while alicyclic or polycarbocyclic substituents imparted high affinity for both subtypes. The σ2 binding and subtype selectivities of N-arylalkyl-7-azanorbornanes was generally greater than the analogously-substituted pyrrolidines, indicating that steric bulk and conformational restriction around the nitrogen atom are likely important for subtype discrimination.