221121-30-8Relevant articles and documents
Microwave-assisted synthesis, biological evaluation and molecular docking studies of new coumarin-based 1,2,3-triazoles
Ashok, D.,Dharavath, Ravinder,Jyothi, K.,Nagaraju, Nalaparaju,Prashanthi, G.,Reddy, M. Ram,Sarasija, M.,Vani, T.,Vijjulatha, M.
, p. 11615 - 11623 (2020/04/09)
Coumarin-based 1,4-disubstituted 1,2,3-triazole derivatives were synthesized using a highly efficient, eco-friendly protocol via a copper(i)-catalyzed click reaction between various substituted arylazides and terminal alkynes. The synthetic route was easy
Exploiting the Imidazolium Effect in Base-free Ammonium Enolate Generation: Synthetic and Mechanistic Studies
Young, Claire M.,Stark, Daniel G.,West, Thomas H.,Taylor, James E.,Smith, Andrew D.
supporting information, p. 14394 - 14399 (2016/11/11)
N-Acyl imidazoles and catalytic isothiourea hydrochloride salts function as ammonium enolate precursors in the absence of base. Enantioselective Michael addition–cyclization reactions using different α,β-unsaturated Michael acceptors have been performed to form dihydropyranones and dihydropyridinones with high stereoselectivity. Detailed mechanistic studies using RPKA have revealed the importance of the “imidazolium” effect in ammonium enolate formation and have highlighted key differences with traditional base-mediated processes.
New Tetracyclic Derivatives of Imidazobenzodiazepines and of Imidazothienodiazepines
Gerecke, Max,Kyburz, Emilio,Borer, Rene,Gassner, Walter
, p. 693 - 722 (2007/10/02)
The synthesis of new tetracyclic 1,4-diazepine derivatives is described.In these compounds, an additional five-membered heterocycle is fused on the known tricyclic ring systems imidazobenzodiazepine and imidazothienodiazepine.Many of these new compounds display a very high affinity to the benzodiazepine receptor in mammals.
