221121-48-8

Basic information

• Product Name: ethyl 4-(2,6-difluorophenyl)-2-methyl-3-oxobutanoate
• Synonyms: ethyl 4-(2,6-difluorophenyl)-2-methyl-3-oxobutanoate
• CAS NO: 221121-48-8
• Molecular Weight: 256.249
• Mol File: 221121-48-8.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: ethyl 4-(2,6-difluorophenyl)-2-methyl-3-oxobutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-(2,6-difluorophenyl)-2-methyl-3-oxobutanoate(221121-48-8)
• EPA Substance Registry System: ethyl 4-(2,6-difluorophenyl)-2-methyl-3-oxobutanoate(221121-48-8)

Safety Data

• Hazardous Substances Data: 221121-48-8(Hazardous Substances Data)

Upstream product

• 654-01-3 (2,6-difluorophenyl)acetonitrile 
• 535-11-5 Ethyl 2-bromopropionate 
• 85068-28-6 2,6-difluorophenylacetic acid 
• 103362-70-5 potassium ethyl methylmalonate 
• 221121-33-1 2-(2,6-difluoro-phenyl)-1-imidazol-1-yl-ethanone 

Downstream Products

• 1307311-09-6 2-[(4-fluorophenylamino)carbonylmethylthio]-6-(2,6-difluorobenzyl)-5-methylpyrimidin-4(3H)-one 
• 1304538-57-5 2-[(4-chlorophenylamino)carbonylmethylthio]-6-(2,6-difluorobenzyl)-5-methylpyrimidin-4(3H)-one 
• 1304538-58-6 2-[(4-bromophenylamino)carbonylmethylthio]-6-(2,6-difluorobenzyl)-5-methylpyrimidin-4(3H)-one 
• 1304538-59-7 2-[(4-methoxyphenylamino)carbonylmethylthio]-6-(2,6-difluorobenzyl)-5-methylpyrimidin-4(3H)-one 
• 1307311-10-9 2-[(4-nitrophenylamino)carbonylmethylthio]-6-(2,6-difluorobenzyl)-5-methylpyrimidin-4(3H)-one 
• 1307311-11-0 2-[(4-cyanophenylamino)carbonylmethylthio]-6-(2,6-difluorobenzyl)-5-methylpyrimidin-4(3H)-one 
• 1281819-08-6 4-(4-(2,6-difluorobenzyl)-5-methyl-6-oxo-1,6-dihydropyrimidin-2-ylamino)benzonitrile 
• 1281819-30-4 4-(4-amino-6-(2,6-difluorobenzyl)-5-methylpyrimidin-2-ylamino)benzonitrile 
• 1281819-23-5 4-(4-(2,6-difluorobenzyl)-5-methylpyrimidin-2-ylamino)benzonitrile 
• 1281819-17-7 4-(4-chloro-6-(2,6-difluorobenzyl)-5-methylpyrimidin-2-ylamino)benzonitrile 
• 221122-03-8 2-butylsulfanyl-6-(2,6-difluoro-benzyl)-3H-pyrimidin-4-one 
• 221122-19-6 2-sec-butylsulfanyl-6-(2,6-difluoro-benzyl)-5-methyl-3H-pyrimidin-4-one 
• 221122-15-2 6-(2,6-difluorophenylmethyl)-3,4-dihydro-2-methylthio-5-methylpyrimidin-4(3H)-one 
• 872422-58-7 6-(2,6-difluoro-benzyl)-5-methyl-2-(4-nitro-benzylsulfanyl)-3H-pyrimidin-4-one 

Relevant articles and documents

Synthesis and biological evaluation of 6-substituted 5-Alkyl-2-(phenylaminocarbonylmethylthio)pyrimidin-4(3H)-ones as potent HIV-1 NNRTIs

A series of new 5-alkyl-2-phenylaminocarbonylmethylthiopyrimidin-4(3H)-ones bearing variously substituted arylmethyl moieties at the C6 position of the pyrimidine ring were synthesized and evaluated for anti-HIV activity in MT-4 cells. Most of these new c

5-alkyl-6-benzyl-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones, a series of anti-HIV-1 agents of the dihydro-alkoxy-benzyl-oxopyrimidine family with peculiar structure - Activity relationship profile

A series of dihydro-alkylthio-benzyl-oxopyrimidines (S-DABOs) bearing a 2-aryl-2-oxoethylsulfanyl chain at pyrimidine C2, an alkyl group at C5, and a 2,6-dichloro-, 2-chloro-6-fluoro-, and 2,6-difluoro-benzyl substitution at C6 (oxophenethyl-S-DABOs, 6-8)

Dihydro-alkylthio-benzyl-oxopyrimidines as inhibitors of reverse transcriptase: Synthesis and rationalization of the biological data on both wild-type enzyme and relevant clinical mutants

A series of novel S-DABO analogues, characterized by different substitution patterns at positions 2, 5, and 6 of the heterocyclic ring, were synthesized in a straightforward fashion by means of parallel synthesis and evaluated as inhibitors of human immun