221158-41-4

Basic information

• Product Name: 4-(3,4-dimethoxyphenyl)-1-phenylbutan-1-one
• Synonyms: 4-(3,4-dimethoxyphenyl)-1-phenylbutan-1-one
• CAS NO: 221158-41-4
• Molecular Weight: 284.355
• Mol File: 221158-41-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-(3,4-dimethoxyphenyl)-1-phenylbutan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3,4-dimethoxyphenyl)-1-phenylbutan-1-one(221158-41-4)
• EPA Substance Registry System: 4-(3,4-dimethoxyphenyl)-1-phenylbutan-1-one(221158-41-4)

Safety Data

• Hazardous Substances Data: 221158-41-4(Hazardous Substances Data)

Upstream product

• 29526-96-3 1-phenylcyclopropan-1-ol 
• 52417-29-5 4-(3,4-dimethoxyphenyl)butanal 
• 56880-86-5 4-(3,4-dimethoxyphenyl)butan-1-ol 
• 13575-74-1 4-(3,4-dimethoxyphenyl)butanoic acid 
• 946412-69-7 4-(3,4-dimethoxyphenyl)-1-phenylbutan-1-ol 

Downstream Products

• 946412-82-4 1,2-dimethoxy-4-(4-phenylbutyl)benzene 
• 78238-94-5 6,7-dimethoxy-1-phenyl-1,2,3,4-tetrahydronaphthalene 

Relevant articles and documents

Ni-Catalyzed β-Alkylation of Cyclopropanol-Derived Homoenolates

Metal homoenolates are valuable synthetic intermediates which provide access to β-functionalized ketones. In this report, we disclose a Ni-catalyzed β-alkylation reaction of cyclopropanol-derived homoenolates using redox-active N-hydroxyphthalimide (NHPI) esters as the alkylating reagents. The reaction is compatible with 1°, 2°, and 3° NHPI esters. Mechanistic studies imply radical activation of the NHPI ester and 2e β-carbon elimination occurring on the cyclopropanol.