221198-99-8

Basic information

• Product Name: 3-Fluoro-4-(4-methylpiperazin-1-yl)aniline
• Synonyms: 3-Fluoro-4-(4-methylpiperazin-1-yl)aniline;[3-fluoro-4-(4-methylpiperazin-1-yl)phenyl]amine dihydrochloride;3-fluoro-4-(4-methyl-1-pi...;3-fluoro-4-(4-Methyl-1-piperazinyl)benzenaMine;3-Fluoro-4-(4-Methyl-1-piperazinyl)aniline;1-(4-Amino-2-fluorophenyl)-4-methylpiperazine;3-Fluoro-4-(4-methylpiperazin-1-yl)phenylamine
• CAS NO: 221198-99-8
• Molecular Formula: C₁₁H₁₆FN₃
• Molecular Weight: 209.2632432
• Mol File: 221198-99-8.mol
• Article Data: 23

Chemical Properties

• Melting Point: 87-89
• Boiling Point: 349.457°C at 760 mmHg
• Flash Point: 165.146°C
• Appearance: /
• Density: 1.167g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.572
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 7.56±0.42(Predicted)
• CAS DataBase Reference: 3-Fluoro-4-(4-methylpiperazin-1-yl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Fluoro-4-(4-methylpiperazin-1-yl)aniline(221198-99-8)
• EPA Substance Registry System: 3-Fluoro-4-(4-methylpiperazin-1-yl)aniline(221198-99-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 221198-99-8(Hazardous Substances Data)

Usage

General Description

3-Fluoro-4-(4-methylpiperazin-1-yl)aniline is a chemical compound characterized by the presence of a fluoro group, a methylpiperazin group, and an aniline group. Often used as a research or experimental chemical, its exact properties can vary depending on its specific molecular structure. Like other chemicals in the aniline family, it has a basic nitrogen atom, and its characteristics and reactivity are greatly influenced by the presence of the methylpiperazin and fluoro groups. It is generally considered an organic compound because of its carbon content. The specific applications and hazards of this substance would depend on further details of its chemical structure and purity.

InChI:InChI=1/C11H16FN3/c1-14-4-6-15(7-5-14)11-3-2-9(13)8-10(11)12/h2-3,8H,4-7,13H2,1H3

Upstream product

• 109-01-3 1-methyl-piperazine 
• 221198-29-4 3-fluoro-4-(4-methylpiperazin-1-yl)nitrobenzene 
• 369-34-6 3,4-difluoronitrobenzene 

Downstream Products

• 1401732-63-5 N-(3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)-1-(4-methoxybenzyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-5-amine 
• 1542257-60-2 3-(3-fluoro-4-(4-methylpiperazin-1-yl)phenyl)-2,6-dimethylpyrimidine-4(3H)-one 
• 1352207-52-3 1-(4-bromo-2-fluorophenyl)-4-methylpiperazine 
• 943745-80-0 (4Z)-6-bromo-4-({[3-fluoro-4-(4-methylpiperazin-1-yl)phenyl]amino}methylene)-isoquinoline-1,3(2H,4H)-dione 
• 1050499-92-7 2-(3-(2-(3-fluoro-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-ylamino)phenyl)acetonitrile 

Relevant articles and documents

NOVEL SULFONAMIDE DERIVATIVE WITH FUSED PYRIMIDINE SKELETON, HAVING EPIDERMAL GROWTH FACTOR RECEPTOR MUTATION INHIBITORY EFFECT

The present invention relates to a novel fused pyrimidine based sulfonamide derivative represented by Formula I, a solvate thereof, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition including the same as an active ingredient. The novel fused pyrimidine based sulfonamide derivative of the present invention can effectively suppress the growth of cancer cells and resistance to drugs, which are induced by mutations in the tyrosine kinase domain of epidermal growth factor receptors, or the growth of cancer cells having such resistance.

NOTCH INHIBITORS AND USES THEREOF

Disclosed herein, inter alia, are compounds for inhibiting Notch and uses thereof.

TETRAHYDROBENZOFURO[2,3-C]PYRIDINE AND BETA-CARBOLINE COMPOUNDS FOR THE TREATMENT, ALLEVIATION OR PREVENTION OF DISORDERS ASSOCIATED WITH TAU AGGREGATES

The present invention relates to novel compounds of formula (I) that can be employed in the treatment, alleviation or prevention of a group of disorders and abnormalities associated with Tau (Tubulin associated unit) protein aggregates including, but not limited to, Neurofibrillary Tangles (NFTs), such as Alzheimer's disease (AD).