22121-58-0 Usage
Description
2-(2,6-Dichloroanilino) benzaldehyde, also known as Diclofenac EP Impurity B, is an organic compound that serves as an impurity in the synthesis of Diclofenac (D436450). It is characterized by its yellow solid appearance and is derived from the chemical properties of its constituent elements.
Uses
Used in Pharmaceutical Industry:
2-(2,6-Dichloroanilino) benzaldehyde is used as an impurity in the production of Diclofenac (D436450) for its anti-inflammatory properties. It plays a significant role in the synthesis process, contributing to the overall effectiveness of the final pharmaceutical product.
Additionally, as an impurity, it is essential to monitor and control the levels of 2-(2,6-Dichloroanilino) benzaldehyde in the manufacturing process to ensure the safety, efficacy, and quality of Diclofenac, which is widely used for its anti-inflammatory and analgesic effects.
Used in Quality Control and Analysis:
In the field of quality control and chemical analysis, 2-(2,6-Dichloroanilino) benzaldehyde is utilized for the identification, quantification, and assessment of its presence as an impurity in Diclofenac. This helps in maintaining the standards and regulatory compliance for the pharmaceutical product, ensuring the safety and well-being of patients who rely on Diclofenac for its therapeutic benefits.
Check Digit Verification of cas no
The CAS Registry Mumber 22121-58-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,1,2 and 1 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 22121-58:
(7*2)+(6*2)+(5*1)+(4*2)+(3*1)+(2*5)+(1*8)=60
60 % 10 = 0
So 22121-58-0 is a valid CAS Registry Number.
22121-58-0Relevant articles and documents
FeCl3-catalyzed oxidative decarboxylation of aryl/heteroaryl acetic acids: Preparation of selected API impurities
Gangadurai, Chinnakuzhanthai,Illa, Giri Teja,Reddy, D. Srinivasa
, p. 8459 - 8466 (2020/11/05)
There is an ever-increasing demand for impurity compounds for use in impurity profiling as regulatory agencies seek information during registration. Herein, we report the FeCl3-catalyzed oxidative decarboxylation of aryl- and heteroaryl acetic acids to the corresponding carbonyl compounds. A variety of useful aldehydes and ketones were prepared in a simple one-pot transformation by employing an environmentally benign, low-cost, and readily available iron salt. The utility of this method has been demonstrated by preparing five valuable API impurities including a multi-gram-scale synthesis of ketorolac impurity B for the first time. This journal is
