22121-86-4Relevant articles and documents
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Monnin
, p. 1983,1987 (1957)
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A tandem "on-palladium" Heck-Jeffery amination route toward the synthesis of functionalized indole-2-carboxylates
McNulty, James,Keskar, Kunal
supporting information; experimental part, p. 6902 - 6908 (2012/01/02)
A direct synthesis of functionalized indole-2-carboxylates involving a PdII-catalyzed annulation of ortho-iodoanilines onto a vinyl ether is described. The reaction mechanism is shown to be distinct from a stepwise Heck, intramolecular amination pathway, likely involving a tandem "on-palladium" Heck-Jeffery amination process incorporating a novel intramolecular amination step.
Synthese de la (+/-)-5-Hydroxy-4-Oxo-Norvaline mettant en jeu l'osmylation d'un alcene fonctionnel.
David, Katerine,Cazes, Bernard,Gore, Jacques
, p. 2768 - 2792 (2007/10/03)
The allylation of a glycine equivalent with 2,3-difunctionalized propenes, eventually made in the presence of a Pd(0) complex, leads to compounds the osmylation of which allows in several cases the obtention of (+/-)-5-Hydroxy-4-Oxo-Norvaline in good yield.From a systemic study have emerged the two partners able to produce the target amino-acid in the best conditions.This one was obtained by a three-step sequence from 1,3-dibromopropene and ethyl N-acetamidomalonate with a 75percent overall yield.