221238-95-5Relevant articles and documents
Potential silicon-containing antifolates
Taylor, Edward C.,Chaudhuri, Rajendra P.,Watson, Samuel E.
, p. 1631 - 1638 (2007/10/03)
Novel silicon-containing folate derivatives were synthesized as potential inhibitors of folate-dependent enzymes in an attempt to develop more effective antitumor agents. A dimethylsilyl moiety was inserted into the sidechain of two known antifolates with the aim of improving passive transport properties and sidechain conformational flexibility. An efficient, convergent palladium-catalyzed coupling methodology was used to link known heterocycles to novel, highly functionalized vinyl and ethynyl silanes.