2213-09-4Relevant articles and documents
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Koretskaya,N.I. et al.
, (1965)
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DIURETICS
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Page/Page column 23, (2011/05/11)
A compound having the structure (I) wherein R is selected from the group consisting of 1) and 2), or a pharmaceutically acceptable salt thereof, and methods of using the compounds for treating hypertension.
Preparation of 2-(3-Bromo-1-methylpropyl)-1,3-dioxolan and the Corresponding Chloride from 2-Methylbutyrolactone
Collins, David J.,James, Alison M.
, p. 223 - 228 (2007/10/02)
Lithium aluminium hydride reduction of ethyl 4-chloro-2-methylbutanoate (4a), derived from 3-methyldihydrofuran-2(3H)-one (2-methylbutyrolactone) (1), gave 4-chloro-2-methylbutan-1-ol (5a), oxidation of which with pyridinium chlorochromate afforded 4-chloro-2-methylbutanal (8a).The aldehyde (8a) was converted into 2-(3'-chloro-1'-methylpropyl)-1,3-dioxolan (7a) in 47percent overall yield from (1). 2-(3'-Bromo-1'-methylpropyl)-1,3-dioxolan (7b) was similarly obtained in 49percent overall yield from (1).Attempted conversion of 3-methyltetrahydrofuran-2-ol (2) into the corresponding cyclic ethylene acetal gave epimeric mixtures of 2-(3'-methyltetrahydrofuran-2'-yloxy)ethanol (6) and 2,2'-ethylenedioxybis(3-methyltetrahydrofuran) (9).