221310-31-2

Basic information

• Product Name: {(1S,2S)-1-Benzyl-2-hydroxy-3-[5-(2-hydroxy-ethylcarbamoyl)-pentylcarbamoyl]-propyl}-carbamic acid tert-butyl ester
• Synonyms: {(1S,2S)-1-Benzyl-2-hydroxy-3-[5-(2-hydroxy-ethylcarbamoyl)-pentylcarbamoyl]-propyl}-carbamic acid tert-butyl ester
• CAS NO: 221310-31-2
• Molecular Weight: 465.59
• Mol File: 221310-31-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: {(1S,2S)-1-Benzyl-2-hydroxy-3-[5-(2-hydroxy-ethylcarbamoyl)-pentylcarbamoyl]-propyl}-carbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: {(1S,2S)-1-Benzyl-2-hydroxy-3-[5-(2-hydroxy-ethylcarbamoyl)-pentylcarbamoyl]-propyl}-carbamic acid tert-butyl ester(221310-31-2)
• EPA Substance Registry System: {(1S,2S)-1-Benzyl-2-hydroxy-3-[5-(2-hydroxy-ethylcarbamoyl)-pentylcarbamoyl]-propyl}-carbamic acid tert-butyl ester(221310-31-2)

Safety Data

• Hazardous Substances Data: 221310-31-2(Hazardous Substances Data)

Upstream product

• 221310-30-1 [5-(2-Hydroxy-ethylcarbamoyl)-pentyl]-carbamic acid tert-butyl ester 
• 6404-29-1 6-(tert-butoxycarbonylamino)hexanoic acid 
• 35408-82-3 6-Amino-N-(2-hydroxyethyl)-capronamid 
• 72155-48-7 (3S,4S)-4-tert-butoxycarbonylamino-3-hydroxy-5-phenylpentanoic acid 

Relevant articles and documents

New renin inhibitors with hydrophilic C-terminus

Four new peptide-based renin inhibitors, Boc-Phe(4-OMe)-MePhe-AHPPA- εAhx-EA (11), Boc-Phe(4-OMe)-MeLeu-AHPPA-eAhx-EA (15), Boc-Phe(4-OMe)- MePhe-Sta-εAhx-EA (20) and Boc-Phe(4-OMe)-MeLeu-Sta-εAhx-EA (21) have been synthesized in search of structures with improved biological properties. They were designed as compounds with moderate hydrophobicity (5.28, 4.79, 4.79 and 4.30), respectively. All synthesized inhibitors were resistant to chymotrypsin activity, all were poorly solubile in buffers pH 2.0 and pH 7.4. The inhibitory potency of renin activity in vitro of 11, 15, 20 and 21 expressed as IC50 was 7.0 x 10-4, 7.5 x 10-5, 6.0 x 10-4 and 2.5 x 10-4 M/l, respectively.