221324-50-1Relevant articles and documents
Screening of a virtual mirror-image library of natural products
Noguchi, Taro,Oishi, Shinya,Honda, Kaori,Kondoh, Yasumitsu,Saito, Tamio,Ohno, Hiroaki,Osada, Hiroyuki,Fujii, Nobutaka
supporting information, p. 7653 - 7656 (2016/07/06)
We established a facile access to an unexplored mirror-image library of chiral natural product derivatives using d-protein technology. In this process, two chemical syntheses of mirror-image substances including a target protein and hit compound(s) allow the lead discovery from a virtual mirror-image library without the synthesis of numerous mirror-image compounds.
Novel esters and amides of nonsteroidal antiinflammatory carboxylic acids as antioxidants and antiproliferative agents
Hellberg, Mark R.,Namil, Abdelmoula,Delgado, Pete,David, Karen C.,Kessler, Timothy L.,Graff, Gustav,Haggard, Karen S.,Nixon, Jon C.
, p. 267 - 276 (2007/10/03)
A series of phenolic antioxidant ester and amide derivatives of the nonsteroidal antiinflammatory drug naproxen was designed to have both antiinflammatory and cytoprotective activity. Compounds were evaluated in vitro both for antioxidant activity, as ass