22134-11-8

Basic information

• Product Name: 2,4,6-TRIBROMOPHENYL ISOTHIOCYANATE
• Synonyms: 1,3,5-Tribromo-2-isothiocyanatobenzene;2,4,6-TRIBROMOPHENYL ISOTHIOCYANATE;2,4,6-TRIBROMOPHENYL ISOTHIOCYANATE 96%;2,4,6-Tribromophenyl isothiocyate, 98%
• CAS NO: 22134-11-8
• Molecular Formula: C₇H₂Br₃NS
• Molecular Weight: 371.87
• Mol File: 22134-11-8.mol
• Article Data: 1

Chemical Properties

• Melting Point: 106 °C
• Boiling Point: 380.1 °C at 760 mmHg
• Flash Point: 183.7 °C
• Appearance: /
• Density: 2.21 g/cm³
• Vapor Pressure: 1.22E-05mmHg at 25°C
• Refractive Index: 1.706
• CAS DataBase Reference: 2,4,6-TRIBROMOPHENYL ISOTHIOCYANATE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,6-TRIBROMOPHENYL ISOTHIOCYANATE(22134-11-8)
• EPA Substance Registry System: 2,4,6-TRIBROMOPHENYL ISOTHIOCYANATE(22134-11-8)

Safety Data

• Statements: R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.; R36/37/38:Irritating to eyes, respiratory system
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36/37/39:Wear suitabl
• HazardClass: IRRITANT-HARMFUL
• Hazardous Substances Data: 22134-11-8(Hazardous Substances Data)

Usage

Description

2,4,6-Tribromophenyl Isothiocyanate is an organic compound characterized by the presence of three bromine atoms at the 2nd, 4th, and 6th positions of a phenyl ring, with an isothiocyanate group attached. 2,4,6-TRIBROMOPHENYL ISOTHIOCYANATE is known for its reactivity and is commonly utilized in the synthesis of various chemical compounds, particularly those with pharmaceutical applications.

Uses

Used in Pharmaceutical Industry:
2,4,6-Tribromophenyl Isothiocyanate is used as a key intermediate compound for the preparation of thiazole derivatives. These thiazole derivatives possess a wide range of biological activities, making them valuable in the development of new pharmaceuticals. The compound plays a crucial role in the synthesis process due to its unique reactivity and structural properties.
In the preparation of thiazole derivative compounds, 2,4,6-Tribromophenyl Isothiocyanate is used as a building block for [application reason] the creation of diverse chemical structures with potential pharmaceutical applications. The compound's bromine atoms and isothiocyanate group contribute to the formation of thiazole derivatives with specific biological activities, which can be further explored and optimized for various therapeutic uses.
Overall, 2,4,6-Tribromophenyl Isothiocyanate is a versatile compound with significant applications in the pharmaceutical industry, particularly in the synthesis of thiazole derivatives with potential therapeutic benefits. Its unique structural features and reactivity make it an essential component in the development of new drugs and pharmaceutical compounds.

InChI:InChI=1/C7H2Br3NS/c8-4-1-5(9)7(11-3-12)6(10)2-4/h1-2H

Upstream product

• 147-82-0 2,4,6-tribromoaniline 

Relevant articles and documents

Novel thiazole derivative compound as well as preparation method, pharmaceutical composition and pharmaceutical application of novel thiazole derivative compound

The invention belongs to the field of pharmaceutical and chemical industries and relates to a compound as shown in a general formula I, a pharmaceutical salt or a hydrate of the compound, a preparation method of the compound as shown in the general formula I, a pharmaceutical composition containing the compound as shown in the general formula I or the pharmaceutical salt or the hydrate of the compound and an application of the compound as shown in the general formula I or the pharmaceutical salt or the hydrate of the compound in production of drugs, wherein the compound as shown in the generalformula I has an effect on inhibiting a PI3K/Akt/mTOR signal pathway of a mammal, all substituent groups in the general formula I are defined as the specification, and the drugs are used for treatingdiseases caused by abnormal expression of the PI3K/Akt/mTOR signal pathway of the mammal.