22135-50-8

Basic information

• Product Name: 4-(4-METHOXYPHENYL)-1-BUTANOL
• Synonyms: 1-(4-methoxy-phenyl)-butan-1-ol;4-METHOXYBENZENEBUTANOL;4-(p-Methoxyphenyl)-1-butanol;1-(4-Methoxyphenyl)-1-Butanol;1-(4-Methoxyphenyl)-1-Butanol(WXC04068)
• CAS NO: 22135-50-8
• Molecular Formula: C₁₁H₁₆O₂
• Molecular Weight: 180.24
• EINECS: 257-782-3
• Mol File: 22135-50-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 3-4 °C(lit.)
• Boiling Point: 160-161 °C8 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.042 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.000377mmHg at 25°C
• Refractive Index: n20/D 1.526(lit.)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(4-METHOXYPHENYL)-1-BUTANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-METHOXYPHENYL)-1-BUTANOL(22135-50-8)
• EPA Substance Registry System: 4-(4-METHOXYPHENYL)-1-BUTANOL(22135-50-8)

Safety Data

• Safety Statements: S24/25:Avoid contact with skin and eyes.
• WGK Germany: 3
• Hazardous Substances Data: 22135-50-8(Hazardous Substances Data)

Usage

Description

4-(4-Methoxyphenyl)-1-butanol is an organic compound that features a butanol molecule with a 4-methoxyphenyl group attached to the fourth carbon atom. It is characterized as a colorless, viscous liquid with a subtle sweet and floral scent. This versatile chemical is utilized in the creation of flavors and fragrances, pharmaceutical intermediates, and due to its antibacterial and antifungal properties, it is a promising candidate for cosmetic and personal care products. Furthermore, its distinctive chemical structure and properties suggest potential applications in the development of innovative drugs and pharmaceuticals.

Uses

Used in Flavor and Fragrance Industry:
4-(4-Methoxyphenyl)-1-butanol is used as a key ingredient in the development of unique fragrances and flavors, capitalizing on its distinctive sweet and floral aroma to enhance various consumer products.
Used in Pharmaceutical Industry:
As a pharmaceutical intermediate, 4-(4-Methoxyphenyl)-1-butanol plays a crucial role in the synthesis of various medicinal compounds, contributing to the development of new drugs and therapies.
Used in Cosmetic and Personal Care Industry:
Leveraging its antibacterial and antifungal properties, 4-(4-Methoxyphenyl)-1-butanol is utilized as an active component in cosmetic and personal care products to ensure cleanliness and prevent microbial contamination.
Used in Drug Development:
4-(4-Methoxyphenyl)-1-butanol's unique chemical structure and properties make it a potential candidate for the development of new pharmaceuticals, opening avenues for research and innovation in the medical field.

InChI:InChI=1/C11H16O2/c1-13-11-7-5-10(6-8-11)4-2-3-9-12/h5-8,12H,2-4,9H2,1H3

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 106-94-5 propyl bromide 
• 693-03-8 n-butyl magnesium bromide 

Downstream Products

• 82749-62-0 N,N-dibutyl-4-methoxylaniline 
• 4160-51-4 1-(4-methoxyphenyl)-1-butanone 
• 1443356-64-6 [1-(4-methoxyphenyl)butoxy]diphenylsilane 
• 91970-64-8 2-hydroxy-1-(4-methoxyphenyl)butan-1-one 
• 1032174-10-9 1-(4-methoxy-3-nitrophenyl)-butan-1-one 

Relevant articles and documents

Discovery of Novel 3-Amino-4-alkoxyphenylketones as PDE4 Inhibitors with Improved Oral Bioavailability and Safety against Spatial Memory Impairments

To realize PDE4 inhibitors with good developmental potentiality for the treatment of dementia, structure-based optimizations of lead compound FCPR03 resulted in novel aminophenylketones 9c and 9H with low nanomolar potency, which displayed comparable acti

Tandem α-Alkylation/Asymmetric Transfer Hydrogenation of Acetophenones with Primary Alcohols

Tandem α-alkylation/asymmetric transfer hydrogenation of acetophenones with primary alcohols, mediated by a single ruthenium catalyst, is described. Under optimized reaction conditions and with use of [Ru(p-cymene)Cl2]2 in combination with an amino acid hydroxyamide ligand, the chiral secondary alcohol products were isolated in moderate yields and in moderate to good enantiomeric excess (up to 89 % ee). One catalyst - one pot - two reactions. Acetophenones are initially alkylated with primary alcohols by the borrowing hydrogen methodology. The alkylation products are directly converted to enantiomerically enriched secondary alcohols.

AROMATIC SUBSTITUTED PENTADIENOIC ACID AMIDE FOR COMBINATION WITH ANTI-INFECTIVE DRUGS

The present invention relates to an aromatic substituted pentadienoic acid amides and there use in combination of specific amounts of aromatic amides i.e. 4-alkyl-5-(substituted phenyl)-2(E),4(E)-pentadienoic acid amides, its geometrical isomers or their dihydro or tetrahydro derivatives and an anti-infective drug useful in potentiating the bioefficacy of antiinfective drug. The combination of the present invention is useful in the treatment of certain infections and disease at lower concentration of anti-infectives necessary to inhibit the growth of microbial strains and may also find applications in reducing the resistance in microorganisms.