221381-89-1

Basic information

• Product Name: benzoic acid, 4-(2-oxo-1-pyrrolidinyl)-, methyl ester
• Synonyms: benzoic acid, 4-(2-oxo-1-pyrrolidinyl)-, methyl ester;methyl 4-(2-oxopyrrolidin-1-yl)benzoate;4-(2-ketopyrrolidin-1-yl)benzoic acid methyl ester;4-(2-oxo-1-pyrrolidinyl)benzoic acid methyl ester;4-(2-Oxo-pyrrolidin-1-yl)-benzoic acid methyl ester;BAS 00358368;CBDivE_015964;ST5449463
• CAS NO: 221381-89-1
• Molecular Formula: C₁₂H₁₃NO₃
• Molecular Weight: 219.23652
• Mol File: 221381-89-1.mol
• Article Data: 14

Chemical Properties

• Melting Point: 118-120 °C(Solv: chloroform (67-66-3); ethyl ether (60-29-7))
• Boiling Point: 447.6±28.0 °C(Predicted)
• Appearance: /
• Density: 1.229±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -2.06±0.20(Predicted)
• CAS DataBase Reference: benzoic acid, 4-(2-oxo-1-pyrrolidinyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: benzoic acid, 4-(2-oxo-1-pyrrolidinyl)-, methyl ester(221381-89-1)
• EPA Substance Registry System: benzoic acid, 4-(2-oxo-1-pyrrolidinyl)-, methyl ester(221381-89-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 221381-89-1(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 36151-44-7 4-(2-oxopyrrolidin-1-yl)benzoic acid 
• 616-45-5 2-pyrrolidinon 
• 1126-46-1 Methyl 4-chlorobenzoate 
• 619-44-3 methyl 4-iodobenzoate 
• 150-13-0 4-amino-benzoic acid 
• 68737-65-5 (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane 
• 619-42-1 4-methoxycarbonylphenyl bromide 
• 99768-12-4 4-methoxycarbonylphenylboronic acid 
• 10338-58-6 N-(4-[methyl 4-benzoxycarbonyl])piperidine 

Downstream Products

• 221381-90-4 1-(4-methoxycarbonyl-2-nitrophenyl)pyrrolidin-2-one 
• 36151-44-7 4-(2-oxopyrrolidin-1-yl)benzoic acid 
• 221381-91-5 1-(4-methoxycarbonyl-2-aminophenyl)pyrrolidin-2-one 
• 221382-11-2 1-<4-methoxycarbonyl-2-(3-pentylamino)phenyl>pyrrolidin-2-one 
• 234110-57-7 1-{2-{[(Amino)(imino)methyl]amino}-4-carboxyphenyl}pyrrolidin-2-one 
• 221381-92-6 1-<4-methoxycarbonyl-2-(N,N'-bis(tert-butyloxycarbonyl)guanidino)phenyl>pyrrolidin-2-one 
• 1204311-22-7 1-(4-(hydroxymethyl)phenyl)pyrrolidin-2-one 
• 36152-29-1 1-(4-(chloromethyl)phenyl)pyrrolidin-2-one 

Relevant articles and documents

Synthetic method of N - aryl substituted lactam compound

The invention discloses a method. NSynthesis method of - aryl substituted lactam compound, and synthesis method thereof is promoted by tertiary butyl hydroperoxide and-tert-butyl hydroperoxideNMulti-step series reaction synthesis - aryl substituted saturated cyclic amine compoundN- Aryl substituted lactam compounds are simple and convenient to operate. The method has the advantages of no transition metal catalysis, wide substrate application range and the like, and is suitable for industrial production.

Selective copper-catalyzed N-arylation of lactams with arylboronic acids under base- and ligand-free conditions

An oxidative copper-catalyzed cross-coupling of arylboronic acids with various ring-size lactams has been developed. The N-arylated lactams were obtained in moderate to excellent yields without any additional bases, ligands, or additives. This reaction shows complete selectivity for N-arylation of lactams in the presence of a hydroxyl group.

NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-COA DESATURASE

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