221539-43-1Relevant articles and documents
Synthesis and evaluation of quinazoline amino acid derivatives as mono amine oxidase (MAO) inhibitors
Khattab, Sherine Nabil,Haiba, Nesreen Saied,Asal, Ahmed Mosaad,Bekhit, Adnan A.,Amer, Adel,Abdel-Rahman, Hamdy M.,El-Faham, Ayman
, p. 3574 - 3585 (2015)
Abstract A series of quinazolinone amino acid ester and quinazolinone amino acid hydrazides were prepared under microwave irradiation as well as conventional condition. The microwave irradiation afforded the product in less reaction time, higher yield and
Total synthesis of asperlicin C, circumdatin F, demethylbenzomalvin A, demethoxycircumdatin H, sclerotigenin, and other fused quinazolinones
Tseng, Ming-Chung,Yang, Huei-Yun,Chu, Yen-Ho
experimental part, p. 419 - 427 (2010/02/16)
Using scandium triflate and microwaves, the direct double dehydrocyclization of anthranilate-containing tripeptides was achieved, affording the total syntheses of (i) quinazolino[3,2-a]benzodiazepinediones (1a-f), (ii) diazepino[2,1-b]quinazolinediones (2a-e), and (iii) pyrazino[2,1-b]quinazolinediones (3a-e) with good overall isolated yields (23-43%, 37-47% and 31-56%, respectively). Among the quinazolino[3,2-a] benzodiazepinediones synthesized, 1a (sclerotigenin), 1b (circumdatin F), and 1f (asperlicin C) are natural products.