221553-72-6 Usage
Description
Lopinavir Metabolite M-3/M-4 is a major metabolite of Lopinavir, an HIV-1 protease inhibitor. It has gained attention as a COVID-19 related research product.
Uses
Used in Pharmaceutical Industry:
Lopinavir Metabolite M-3/M-4 is used as a research compound for studying its potential role in the treatment of COVID-19. As a metabolite of Lopinavir, it may contribute to the overall therapeutic effect of the drug in combating the virus.
Used in HIV Treatment:
Lopinavir Metabolite M-3/M-4 is used as a component of Lopinavir, which is an HIV-1 protease inhibitor. It plays a role in the overall efficacy of the drug in treating HIV infections by inhibiting the activity of the viral protease enzyme, thereby preventing the formation of mature, infectious viral particles.
Check Digit Verification of cas no
The CAS Registry Mumber 221553-72-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,1,5,5 and 3 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 221553-72:
(8*2)+(7*2)+(6*1)+(5*5)+(4*5)+(3*3)+(2*7)+(1*2)=106
106 % 10 = 6
So 221553-72-6 is a valid CAS Registry Number.
InChI:InChI=1/C37H48N4O6/c1-24(2)34(41-19-18-32(43)40-37(41)46)36(45)38-29(20-27-14-7-5-8-15-27)22-31(42)30(21-28-16-9-6-10-17-28)39-33(44)23-47-35-25(3)12-11-13-26(35)4/h5-17,24,29-32,34,42-43H,18-23H2,1-4H3,(H,38,45)(H,39,44)(H,40,46)/t29?,30?,31-,32?,34-/m0/s1
221553-72-6Relevant articles and documents
Synthesis and antiviral activities of the major metabolites of the HIV protease inhibitor ABT-378 (Lopinavir)
Sham, Hing L,Betebenner, David A,Herrin, Thomas,Kumar, Gondi,Saldivar, Ayda,Vasavanonda, Sudthida,Molla, Akhter,Kempf, Dale J,Plattner, Jacob J,Norbeck, Daniel W
, p. 1351 - 1353 (2007/10/03)
The HIV protease inhibitor ABT-378 (Lopinavir) is metabolized rapidly and extensively by CYP-3A4 catalyzed oxidation. Three of the major metabolites identified were synthesized and their antiviral (HIV) activities determined.