22156-23-6

Basic information

• Product Name: N-(1-methoxyethyl)phthalimide
• Synonyms: N-(1-methoxyethyl)phthalimide
• CAS NO: 22156-23-6
• Molecular Weight: 205.213
• Mol File: 22156-23-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(1-methoxyethyl)phthalimide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(1-methoxyethyl)phthalimide(22156-23-6)
• EPA Substance Registry System: N-(1-methoxyethyl)phthalimide(22156-23-6)

Safety Data

• Hazardous Substances Data: 22156-23-6(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 3485-84-5 N-vinylphthalimide 
• 201230-82-2 carbon monoxide 

Downstream Products

• 101207-49-2 N-[1-(4-methylphenyl)ethyl]phthalimide 
• 107275-17-2 N-[1-(4-methoxyphenyl)ethyl]phthalimide 

Relevant articles and documents

Asymmetric Hydroformylation and Hydrocarboxylation of Enamides. Synthesis of Alanine and Proline

Carbonyltris(triphenylphosphine)hydridorhodium (1) catalyzed the hydroformylation of N-vinylimides in the presence of optically active 2,3-O-isopropylidene-2,3-dihydroxy-1,4-bis(diphenylphosphino)butane (DIOP) or 2,3-O-isopropylidene-2,3-dihydroxy-1,4-bis(5H-dibenzophospholyl)butane (DIPHOL) to afford optically active α-amido aldehydes.Linear disubstituted N-vinylimides or -amides reacted very sluggishly, while the cyclic N-acyl-2-pyrroline (19) was very reactive.In the unsubstituted N-vinylimides moderate (20-40percent ee) asymmetric induction was observed.The optically active α-amido aldehydes were readily converted to the corresponding α-amino acids.Asymmetric hydrocarboxylation of the same substrates in the presence of bis(triphenylphosphine)palladium chloride (2) produced α-amido esters in low optical purity.