221635-42-3

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Basic information

Product Name: 2,5-Di(1-aziridinyl)-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone
Synonyms: NSC-697726; RH1; 2,5-bis(aziridin-1-yl)-3-(hydroxymethyl)-6-methylcyclohexa-2,5-diene-1,4-dione
CAS NO:221635-42-3
Molecular Formula: C₁₂H₁₄N₂O₃
Molecular Weight: 234.2512
EINECS: N/A
Product Categories: N/A
Mol File: 221635-42-3.mol
Article Data: 2

Chemical Properties

Melting Point: N/A
Boiling Point: 424.8°C at 760 mmHg
Flash Point: 210.7°C
Appearance: N/A
Density: 1.536g/cm³
Vapor Pressure: 5.38E-09mmHg at 25°C
Refractive Index: 1.712
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: 2,5-Di(1-aziridinyl)-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone(CAS DataBase Reference)
NIST Chemistry Reference: 2,5-Di(1-aziridinyl)-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone(221635-42-3)
EPA Substance Registry System: 2,5-Di(1-aziridinyl)-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone(221635-42-3)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 221635-42-3(Hazardous Substances Data)

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2,5-Cyclohexadiene-1,4-dione,2,5-bis(1-aziridinyl)-3-(hydroxymethyl)-6-methyl-
Cas No: 221635-42-3
USD $ 3.0-3.0 / Kilogram
1 Kilogram
1-100 Metric Ton/Month
Dayang Chem (Hangzhou) Co.,Ltd.
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2,5-Di(1-aziridinyl)-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone
Cas No: 221635-42-3
No Data
100 Gram
1000 Kilogram/Month
Henan Tianfu Chemical Co., Ltd.
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2,5-Cyclohexadiene-1,4-dione,2,5-bis(1-aziridinyl)-3-(hydroxymethyl)-6-methyl- cas 221635-42-3
Cas No: 221635-42-3
No Data
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Hangzhou Fandachem Co.,Ltd
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221635-42-3 Usage

Origin

Derived from the bacterium Streptomyces caespitosus

Classification

Powerful antibiotic and antitumor agent

Mechanism of action

Causes DNA and RNA cross-linking, leading to cell death
Stomach cancer
Pancreas cancer
Bladder cancer
Lung cancer
Glaucoma
Rheumatoid arthritis

Side effects

Can cause bone marrow depression and suppress the immune system

Medical considerations

Requires careful monitoring and dosing adjustments during treatment

Check Digit Verification of cas no

The CAS Registry Mumber 221635-42-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,1,6,3 and 5 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 221635-42:
(8*2)+(7*2)+(6*1)+(5*6)+(4*3)+(3*5)+(2*4)+(1*2)=103
103 % 10 = 3
So 221635-42-3 is a valid CAS Registry Number.

221635-42-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name	2,5-di(aziridin-1-yl)-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone

1.2 Other means of identification

Product number	-
Other names	RH1

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:221635-42-3 SDS

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221635-42-3Relevant articles and documents

DT-DIAPHORASE-ACTIVE AGENTS FOR TREATMENT OF PEDIATRIC TUMORS

-

Page/Page column 12, (2009/05/29)

The present invention is directed to methods for treating patients having a pediatric cancer, comprising administering to a patient an effective amount of the compound 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone (RH1). The cancer can incl

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