2220-12-4

Basic information

• Product Name: 9,10-dimethoxy-13-methyl-5,13a-dihydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinoline
• CAS NO: 2220-12-4
• Molecular Formula: C₂₁H₂₀NO₄*I
• Molecular Weight: 351.3957
• Mol File: 2220-12-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 613°C at 760 mmHg
• Flash Point: 186.6°C
• Density: 1.33g/cm³
• Vapor Pressure: 5.79E-15mmHg at 25°C
• Refractive Index: 1.662
• CAS DataBase Reference: 9,10-dimethoxy-13-methyl-5,13a-dihydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 9,10-dimethoxy-13-methyl-5,13a-dihydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinoline(2220-12-4)
• EPA Substance Registry System: 9,10-dimethoxy-13-methyl-5,13a-dihydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinoline(2220-12-4)

Safety Data

• Hazardous Substances Data: 2220-12-4(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 483-15-8 7,8-dihydroberberine 
• 39024-13-0 acetoneberberine 
• 74-88-4 methyl iodide 
• 633-65-8 berberine chloride 

Downstream Products

• 478-12-6 Thalictricavin 

Relevant articles and documents

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NOVEL ISOQUINOLINE DERIVATIVES

A compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 to R7 have the significance given in claim 1, can be used in the form of a pharmaceutical composition.

13,13a-DIHYDROBERBERINE DERIVATIVES, THEIR PHARMACEUTICAL COMPOSITION AND USE

The present invention provides 13,13a-dihydroberberine derivatives or their physiologically acceptable salts represented by the following formula, pharmaceutical compositions comprising the same, and uses thereof. The 13,13a-dihydroberberine derivatives have an activity of promoting glucose absorption in muscle cells, and the whole animal tests show that the present compounds have effects on improving glucose-tolerance and insulin-resistance, facilitating weight loss, relieving fatty liver and the like. Thus, the present compounds can be used in treating diabetes mellitus, adiposity, fatty liver and complications thereof induced by insulin resistance.

Syntheses and absorption spectra of some compounds with the berbine structure

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