2220-42-0

Basic information

• Product Name: 4,4-dimethylcholest-5-en-3-one
• Synonyms: 4,4-Dimethylcholest-5-en-3-one; Cholest-5-en-3-one, 4,4-dimethyl-
• CAS NO: 2220-42-0
• Molecular Formula: C₂₉H₄₈O
• Molecular Weight: 412.6908
• Mol File: 2220-42-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 490.2°C at 760 mmHg
• Flash Point: 204°C
• Density: 0.97g/cm³
• Vapor Pressure: 9.32E-10mmHg at 25°C
• Refractive Index: 1.516
• CAS DataBase Reference: 4,4-dimethylcholest-5-en-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4-dimethylcholest-5-en-3-one(2220-42-0)
• EPA Substance Registry System: 4,4-dimethylcholest-5-en-3-one(2220-42-0)

Safety Data

• Hazardous Substances Data: 2220-42-0(Hazardous Substances Data)

Upstream product

• 601-54-7 Δ⁵-cholesten-3-one 
• 601-57-0 cholest-4-en-3-one 
• 2309-32-2 3-acetoxy-cholesta-3,5-diene 
• 865-47-4 potassium tert-butylate 
• 75-65-0 tert-butyl alcohol 
• 74-88-4 methyl iodide 
• 601-54-7 Cholest-5-en-3-one 
• 601-57-0 Cholest-4-en-3-one 
• 109-99-9 tetrahydrofuran 
• 72340-46-6 4,4-dimethylcholesteryl nitrite 
• 6384-44-7 4,4-dimethylcholesta-1,5-dien-3-one 
• 149396-93-0 5β,6β-epoxy-4,4-dimethylcholest-1-en-3-one 
• 96443-16-2 2α-Brom-4,4-dimethyl-cholesten-(5)-ol-(3α) 
• 30961-22-9 3-Isopropyl-3,5-seco-A-norcholestan-3,5-dion 

Downstream Products

• 2097-85-0 4,4-dimethyl-5α-cholestan-3-one 
• 1253-88-9 4a,4a-dimethylcholest-5-en-3β-ol 
• 2634-49-3 4,4-Dimethyl-cholest-5-en 
• 75508-44-0 4,4-dimethyl-2,2-diphenylcholest-5-en-3-one 
• 2550-84-7 4,4-dimethyl-5α-cholestan-3β-ol 
• 24364-70-3 2-Oximino-4,4-dimethyl-cholest-5-en-3-on 
• 35490-52-9 4',4'-dimethylspiro<1,3-dioxolane-2,3'-cholest-5'-ene> 
• 187676-53-5 4,4-dimethyl-3-tosylhydrazonocholest-5-ene 
• 24364-59-8 2-Diazo-4,4-dimethyl-cholest-5-en-3-on 
• 433301-90-7 3α-p-Toluolsulfonyloxy-4,4-dimethyl-cholesten-(5) 

Relevant articles and documents

Synthesis of a Novel 1α,5α-Cyclocholestane

The synthesis of 4,4-dimethyl-1α,5α-cyclocholesta-3,7-dione (11), by lithium- or ytterbium-liquid ammonia reduction of the bis-α,β-unsaturated ketone, 4,4-dimethylcholesta-1,5-diene-3,7-dione (10), is described.The chemistry of the reductive cyclization is discussed.The 1H NMR spectra of the corresponding dihydroxy derivatives of 11 reveal an unusually high-field signal due to H-9.X-ray diffraction analysis of the 7β-monool 13a indicates that ring B of the steroid nucleus is in a boat conformation and that H-9 partially eclipses the C-1-C-10 bond of the cyclopropyl ring.An anisotropic ring current effect is postulated to account for the chemical shifts of H-9 in these cyclosteroids.The chemistry of these compounds is described.

Montmorillonite clay catalysis. Part 15 backbone rearrangement of 4,4- dialkylcholest-5-enes catalyzed by montmorillonite K-10

In the presence of montmorillonite K-10 4,4-dialkylcholest-5-enes undergo backbone rearrangement to give (20R)- and (20S)-4,4-dialkyl-5β,14β- dimethyl- 18,19-dinor-8α,9β,10α-cholest-13(17)-enes in high yields.

Montmorillonite clay catalysis. Part 31: A new ready and high yield procedure for the cleavage of acetals catalysed by montmorillonite K 10

An easy cleavage of acetals has been carried out in excellent yield under catalysis of montmorillonite K 10 in refluxing wet acetone.

The chemistry of 5β, 6β-epoxy-4,4 dimethylcholest-1-en-3 one. Approaches to the synthesis of 1α, 5α-cyclosteroids. Part II

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