222168-23-2

Basic information

• Product Name: 3-((trimethylsilyl)ethynyl)picolinaldehyde
• Synonyms: 3-((trimethylsilyl)ethynyl)picolinaldehyde
• CAS NO: 222168-23-2
• Molecular Weight: 203.316
• Mol File: 222168-23-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-((trimethylsilyl)ethynyl)picolinaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 3-((trimethylsilyl)ethynyl)picolinaldehyde(222168-23-2)
• EPA Substance Registry System: 3-((trimethylsilyl)ethynyl)picolinaldehyde(222168-23-2)

Safety Data

• Hazardous Substances Data: 222168-23-2(Hazardous Substances Data)

Upstream product

• 38749-79-0 3-bromo-2-picoline 
• 1066-54-2 trimethylsilylacetylene 
• 405174-97-2 3-bromopicolinaldehyde 

Downstream Products

• 1133853-62-9 (R)-8-(4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydro-1,7-naphthyridine 
• 1133854-18-8 (R)-N-(4-cyanophenyl)-8-(4-(trifluoromethyl)phenyl)-5,6-dihydro-1,7-naphthyridine-7(8H)-carboxamide 
• 1133853-61-8 (R)-N-(pyridin-3-yl)-8-(4-(trifluoromethyl)phenyl)-5,6-dihydro-1,7-naphthyridine-7(8H)-carboxamide 
• 1133853-59-4 (R)-N-(4-fluorophenyl)-8-(4-(trifluoromethyl)phenyl)-5,6-dihydro-1,7-naphthyridine-7(8H)-carboxamide 
• 1589601-99-9 8-(3-fluoro-4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydro-1,7-naphthyridine 
• 1133853-58-3 8-(4-(trifluoromethyl)phenyl)-5,6,7,8-tetrahydro-1,7-naphthyridine 
• 1589601-98-8 benzyl 8-(3-fluoro-4-(trifluoromethyl)phenyl)-1,7-naphthyridine-7(8H)-carboxylate 
• 1589602-11-8 (S)-1-(3-fluoro-4-(trifluoromethyl)phenyl)-N-((S)-1,1,1-trifluoropropan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxamide 
• 1589602-10-7 (R)-1-(3-fluoro-4-(trifluoromethyl)phenyl)-N-((S)-1,1,1-trifluoropropan-2-yl)-3,4-dihydroisoquinoline-2(1H)-carboxamide 
• 1589602-07-2 (S)-8-(4-(trifluoromethyl)phenyl)-N-((S)-1,1,1-trifluoropropan-2-yl)-5,6-dihydro-1,7-naphthyridine-7(8H)-carboxamide 
• 1470018-52-0 (R)-8-(4-(trifluoromethyl)phenyl)-N-((S)-1,1,1-trifluoropropan-2-yl)-5,6-dihydro-1,7-naphthyridine-7(8H)-carboxamide 

Relevant articles and documents

Multi-substituted amine compound and its preparation and use (by machine translation)

The invention belongs to the field of medical technology, in particular, the present invention provides the following formula I shown multi-substituted amine compound or its isomer or its pharmaceutically acceptable salt, ester, prodrug or hydrate, its pharmaceutical composition, preparation method thereof and its use in the preparation of medicine for treating aids in use. The compound or pharmaceutical composition containing the compound can be used as an inhibitor for inhibiting HIV integrase with LEDGF/p75 between protein - protein interaction and HIV integrase dimerization, then can be used for the treatment of aids. . (by machine translation)

Synthesis of the pyridinyl analogues of dibenzylideneacetone (pyr-dba) via an improved Claisen-Schmidt condensation, displaying diverse biological activities as curcumin analogues

An efficient and easy procedure to synthesize the pyridinyl analogues of dibenzylideneacetone (pyr-dba) was developed by the condensation of substituted nicotinaldehyde and acetone in the presence of K2CO3 in toluene-EtOH-H2O solvent system. Structurally diverse pyr-dba, including quinolinyl dba, can be prepared conveniently in moderate to excellent yields under mild conditions with this method. The resulting pyr-dba functioned as the enone analogs of curcumin and efficiently inhibited the activation of NF-κB and the growth of colorectal carcinoma HCT116 p53+/+ cells as well as the HIV-1 IN-LEDGF/p75 interaction. The Royal Society of Chemistry 2012.