Cas 22218-55-9,(±)-2,4-cis-7-methoxyflavan-4-ol

22218-55-9

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Basic information

Product Name: (±)-2,4-cis-7-methoxyflavan-4-ol
Synonyms:
CAS NO:22218-55-9
Molecular Formula:
Molecular Weight: 256.301
EINECS: N/A
Product Categories: N/A
Mol File: 22218-55-9.mol
Article Data: 5

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: (±)-2,4-cis-7-methoxyflavan-4-ol(CAS DataBase Reference)
NIST Chemistry Reference: (±)-2,4-cis-7-methoxyflavan-4-ol(22218-55-9)
EPA Substance Registry System: (±)-2,4-cis-7-methoxyflavan-4-ol(22218-55-9)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 22218-55-9(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 22218-55-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,2,1 and 8 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 22218-55:
(7*2)+(6*2)+(5*2)+(4*1)+(3*8)+(2*5)+(1*5)=79
79 % 10 = 9
So 22218-55-9 is a valid CAS Registry Number.

22218-55-9Upstream product

21785-09-1 7-methoxyflavanone

22218-55-9Downstream Products

22218-55-9Relevant articles and documents

Synthesis and evaluation of 4-triazolylflavans as new aromatase inhibitors

Yahiaoui, Samir,Pouget, Christelle,Fagnere, Catherine,Champavier, Yves,Habrioux, Gérard,José Chulia, Albert

, p. 5215 - 5218 (2004)

Aromatase is a target of pharmaceutical interest for the treatment of estrogen-dependent cancers. Azole derivatives such as letrozole or anastrozole have been developed for aromatase inhibition and are used for the treatment of breast tumors. In this paper, four 4-triazolylflavans were synthesized and were found to exhibit moderate to high inhibitory potency against aromatase.

Design, synthesis and evaluation of 4-imidazolylflavans as new leads for aromatase inhibition

Pouget, Christelle,Fagnere, Catherine,Basly, Jean-Philippe,Habrioux, Gerard,Chulia, Albert Jose

, p. 2859 - 2861 (2007/10/03)

Two 4-imidazolylflavans were synthesized and their relative stereochemistry was established by 1H and 13C NMR data. These compounds were tested for their activity to inhibit aromatase. It was observed that the introduction of an imidazolyl group at carbon 4 on flavan nucleus led to potent molecules.

Synthesis and structure of flavan-4-ols and 4-methoxyflavans as new potential anticancer drugs

Pouget, Christelle,Fagnere, Catherine,Basly, Jean-Philippe,Leveque, Hubert,Chulia, Albert-José

, p. 6047 - 6052 (2007/10/03)

Reduction of a series of substituted flavanones afforded synthetic access to flavan-4-ols and was followed for some of them by an S(N)2-type acid-catalysis in methanol to provide 4-methoxyflavans. The stereochemistry of these compounds was established by 1H and 13C NMR data. Flavan-4-ols and 4-methoxyflavans have been resolved into enantiomers which are being evaluated as anticancer drugs. (C) 2000 Elsevier Science Ltd.

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