22227-41-4

Basic information

• Product Name: morpholin-4-yl[3-nitro-5-(trifluoromethyl)phenyl]methanone
• CAS NO: 22227-41-4
• Molecular Formula: C₁₂H₁₁F₃N₂O₄
• Molecular Weight: 304.2219
• Mol File: 22227-41-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 415.333°C at 760 mmHg
• Flash Point: 204.987°C
• Density: 1.442g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.526
• CAS DataBase Reference: morpholin-4-yl[3-nitro-5-(trifluoromethyl)phenyl]methanone(CAS DataBase Reference)
• NIST Chemistry Reference: morpholin-4-yl[3-nitro-5-(trifluoromethyl)phenyl]methanone(22227-41-4)
• EPA Substance Registry System: morpholin-4-yl[3-nitro-5-(trifluoromethyl)phenyl]methanone(22227-41-4)

Safety Data

• Hazardous Substances Data: 22227-41-4(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 328-80-3 3-nitro-5-trifluoromethyl-benzoic acid 
• 782-79-6 3-nitro-5-trifluoromethyl-benzoyl chloride 

Downstream Products

• 874830-95-2 3-(morpholin-4-ylcarbonyl)-5-(trifluoro-methyl)aniline 

Relevant articles and documents

N-Phenyl-N′-[4-(5H-pyrrolo[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as novel inhibitors of VEGFR and FGFR kinases

We have recently reported the discovery of pyrrolo[3,2-d]pyrimidine derivatives 1a and 1b as potent triple inhibitors of vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR), and Tie-2 kinases. To identify compounds having strong inhibitory activity against fibroblast growth factor receptor (FGFR) kinase, further modification was conducted using the co-crystal structure analysis of VEGFR2 and 1b. Among the compounds synthesized, urea derivative 11l having a piperazine moiety on the terminal benzene ring showed strong inhibitory activity against FGFR1 kinase as well as VEGFR2 kinase. A binding model of 11l complexed with VEGFR2 suggested that the piperazine moiety forms additional interactions with Ile1025 and His1026.