222295-27-4

Basic information

• Product Name: methyl 4-(2-amino-4(3H)-5-oxofuro<2,3-d>pyrimidine-5-yl)benzoate
• Synonyms: methyl 4-(2-amino-4(3H)-5-oxofuro<2,3-d>pyrimidine-5-yl)benzoate
• CAS NO: 222295-27-4
• Molecular Weight: 285.259
• Mol File: 222295-27-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: methyl 4-(2-amino-4(3H)-5-oxofuro<2,3-d>pyrimidine-5-yl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 4-(2-amino-4(3H)-5-oxofuro<2,3-d>pyrimidine-5-yl)benzoate(222295-27-4)
• EPA Substance Registry System: methyl 4-(2-amino-4(3H)-5-oxofuro<2,3-d>pyrimidine-5-yl)benzoate(222295-27-4)

Safety Data

• Hazardous Substances Data: 222295-27-4(Hazardous Substances Data)

Upstream product

• 56-09-7 2-aminopyrimidine-4,6-diol 

Downstream Products

• 222295-34-3 4-(2-amino-4(3H)-5-oxofuro<2,3-d>pyrimidine-5-yl)benzoic acid 
• 222295-37-6 diethyl N-<4-(2-amino-5,6-dihydro-4(3H)-5-oxofuro<2,3-d>pyrimidin-5-yl)benzoyl>-L-glutamate 
• 222295-35-4 diethyl N-<4-(2-amino-4(3H)-5-oxofuro<2,3-d>pyrimidin-5-yl)benzoyl>-L-glutamate 
• 222295-36-5 N-<4-(2-amino-4(3H)-5-oxofuro<2,3-d>pyrimidin-5-yl)benzoyl>-L-glutamic acid 

Relevant articles and documents

Synthesis and biological evaluation of 5-arylfuro[2,3-d]pyrimidines as novel dihydrofolate reductase inhibitors

A series of about fifty novel 5-arylfuro[2,3-d]pyrimidine derivatives were synthesized as potential inhibitors of dihydrofolate reductase (DHFR) arising from different species. Weak enzyme inhibition was observed for most of the compounds, with only a few reaching IC50 values less than 30 μM. With regards to antibacterial and antimalarial potency, only seven compounds showed a modest in vitro activity against some bacteria strains and only three products proved significantly active against P. falciparum.