222314-26-3

Basic information

• Product Name: (3S,5S,7aR)-5-allyl-3-phenylhexahydropyrrolo<2,1-b><1,3>oxazole
• Synonyms: (3S,5S,7aR)-5-allyl-3-phenylhexahydropyrrolo<2,1-b><1,3>oxazole
• CAS NO: 222314-26-3
• Molecular Weight: 229.322
• Mol File: 222314-26-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3S,5S,7aR)-5-allyl-3-phenylhexahydropyrrolo<2,1-b><1,3>oxazole(CAS DataBase Reference)
• NIST Chemistry Reference: (3S,5S,7aR)-5-allyl-3-phenylhexahydropyrrolo<2,1-b><1,3>oxazole(222314-26-3)
• EPA Substance Registry System: (3S,5S,7aR)-5-allyl-3-phenylhexahydropyrrolo<2,1-b><1,3>oxazole(222314-26-3)

Safety Data

• Hazardous Substances Data: 222314-26-3(Hazardous Substances Data)

Upstream product

• 205442-89-3 (3S,5R,7aR)-5-(benzotriazol-1-yl)-3-phenyl<2,1-b>oxazolopyrrolidine 
• 762-72-1 allyl-trimethyl-silane 

Downstream Products

• 222314-33-2 (S)-2-((2S,5R)-2-Allyl-5-phenethyl-pyrrolidin-1-yl)-2-phenyl-ethanol 
• 222314-32-1 (S)-2-((2S,5R)-2-Allyl-5-pentyl-pyrrolidin-1-yl)-2-phenyl-ethanol 
• 222314-29-6 (S)-2-((2S,5S)-2-Allyl-5-pentyl-pyrrolidin-1-yl)-2-phenyl-ethanol 
• 222314-34-3 (2S)-2-<(2S,5S)-2-allyl-5-phenyltetrahydro-1H-pyrrol-1-yl>-2-phenyl-1-ethanol 

Relevant articles and documents

Asymmetric syntheses of 2-substituted and 2,5-disubstituted pyrrolidines from (3S,5R,7aR)-5-(benzotriazol-1-yl)-3-phenyl[2,1-b]oxazolopyrrolidine

Benzotriazole, 2,5-dimethoxytetrahydrofuran, and (S)-phenylglycinol in one step gave 80% of (3S, 5R,7aR)-5-(benzotriazol-1-yl)-3-phenyl-[2,1- b]oxazolopyrrolidine (6), whose crystal structure was confirmed by X-ray crystallography. Novel chiral pyrrolidine synthon 6 reacts with organosilicon (allyltrimethylsilanes and vinyloxytrimethylsilanes), organophosphorus, organozinc, and Grignard reagents to afford chiral 2-substituted and 2,5- disubstituted pyrrolidines.