22246-00-0

Basic information

• Product Name: 6-AMINO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE
• Synonyms: 6-AMINO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE;6-AMINO-3,4-DIHYDROISOQUINOLIN-1(2H)-ONE;6-AMinoisoquinolone;1(2H)-Isoquinolinone, 6-aMino-3,4-dihydro-;6-Amino-3,4-dihydro-1(2H)-isoquinolinone;6-Amino-3,4-dihydro-isocarbostyril;1(2H)-Isoquinolinone, 6-amino-3,4-dihydro-2-methyl-;6-amino-3,4-dihydroisoquinolin-1(2H)-one hydrochloride
• CAS NO: 22246-00-0
• Molecular Formula: C₉H₁₀N₂O
• Molecular Weight: 162.19
• Mol File: 22246-00-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 510.6±50.0 °C(Predicted)
• Appearance: /
• Density: 1.237±0.06 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 15.50±0.20(Predicted)
• CAS DataBase Reference: 6-AMINO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-AMINO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE(22246-00-0)
• EPA Substance Registry System: 6-AMINO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE(22246-00-0)

Safety Data

• Hazardous Substances Data: 22246-00-0(Hazardous Substances Data)

Usage

Description

6-AMINO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE is an organic compound with the molecular formula C9H10N2O. It is a derivative of isoquinolinone, featuring an amino group at the 6th position and a hydrogen atom at the 1st position. 6-AMINO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE is known for its potential applications in the pharmaceutical and chemical industries due to its unique structural properties.

Uses

Used in Pharmaceutical Industry:
6-AMINO-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE is used as an intermediate for the synthesis of benzolactams, which are known as dopamine D3 receptor ligands. These ligands play a crucial role in the development of medications targeting various central nervous system disorders, such as schizophrenia, Parkinson's disease, and attention deficit hyperactivity disorder (ADHD). The compound's ability to interact with dopamine D3 receptors makes it a valuable component in the development of novel therapeutic agents for these conditions.

Downstream Products

• 72299-67-3 1,2,3,4-tetrahydroisoquinolin-6-amine 
• 164148-93-0 6-[(4-cyanobenzoyl)amino]-1,2,3,4-tetrahydroisoquinolineacetic acid 1,1-dimethylethyl ester 
• 164148-94-1 6-[[4-[[[(1,1-dimethylethoxy)carbonyl]amino]iminomethyl]benzoyl]amino]-1,2,3,4-tetrahydroisoquinolineacetic acid 1,1-dimethylethyl ester 

Relevant articles and documents

A kind of diaryl hydanto?n derivatives, its preparation method, pharmaceutical composition and application

Provided are a compound as represented by formula I, or pharmaceutically acceptable salt, solvate, precursor drug, stereoisomer, tautomer, polymorph or metabolite thereof, pharmaceutical composition containing same, and uses thereof in the preparation of drugs for treating androgen receptor related diseases.