22246-66-8

Basic information

• Product Name: 5-METHOXY-2,3-DIHYDRO-ISOINDOL-1-ONE
• Synonyms: 5-METHOXY-2,3-DIHYDRO-ISOINDOL-1-ONE;5-methoxyisoindolin-1-one;2,3-Dihydro-5-methoxy-1H-Isoindol-1-one;5-Methoxy-2,3-dihydro-1H-isoindol-1-one;2,3-Dihydro-6-Methoxy-1H-isoindol-1-on;1H-Isoindol-1-one, 2,3-dihydro-5-Methoxy-
• CAS NO: 22246-66-8
• Molecular Formula: C₉H₉NO₂
• Molecular Weight: 163.17
• Mol File: 22246-66-8.mol
• Article Data: 27

Chemical Properties

• Melting Point: 160-161℃ (acetonitrile ethyl ether )
• Boiling Point: 439.235 °C at 760 mmHg
• Flash Point: 219.442 °C
• Appearance: /
• Density: 1.208±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.565
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.37±0.20(Predicted)
• CAS DataBase Reference: 5-METHOXY-2,3-DIHYDRO-ISOINDOL-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-METHOXY-2,3-DIHYDRO-ISOINDOL-1-ONE(22246-66-8)
• EPA Substance Registry System: 5-METHOXY-2,3-DIHYDRO-ISOINDOL-1-ONE(22246-66-8)

Safety Data

• Hazardous Substances Data: 22246-66-8(Hazardous Substances Data)

Usage

General Description

5-Methoxy-2,3-dihydro-isoindol-1-one is a chemical compound with the molecular formula C11H11NO2. It falls under the category of organic compounds known as isoindolones, which are aromatic compounds containing an isoindole bearing a ketone. It is commonly used in the field of organic chemistry for various scientific and experimental purposes, primarily due to its aromaticity, versatility, and stability. Despite its utilities, little information is available regarding its toxicity or other potential health risks, therefore, the substance should be handled with appropriate safety measures.

InChI:InChI=1/C9H9NO2/c1-12-7-3-2-6-5-10-9(11)8(6)4-7/h2-4H,5H2,1H3,(H,10,11)

Upstream product

• 139557-96-3 (2-iodo-5-methoxyphenyl)methanol 
• 1367075-26-0 C₁₀H₁₁N₃O₃ 
• 15365-25-0 methyl 2-(bromomethyl)-4-(methyloxy)benzoate 
• 1221486-78-7 2-bromomethyl-4-methoxybenzoic acid 
• 50727-04-3 4-methoxyphthalimide 
• 35598-05-1 methyl 4-methoxy-2-methylbenzoate 
• 201230-82-2 carbon monoxide 
• 138642-47-4 2-bromo-5-methoxybenzonitrile 
• 17100-65-1 2-bromo-4-methoxybenzoic acid methyl ester 
• 22246-21-5 2-cyano-4-methoxybenzoic acid methyl ester 
• 5071-96-5 3-METHOXYBENZYLAMINE 
• 1007629-19-7 2-aminomethyl-5-methoxy-benzoic acid methyl ester 
• 127510-95-6 2-cyano-5-methoxybenzoic acid methyl ester 
• 85-44-9 phthalic anhydride 

Downstream Products

• 252061-67-9 4-(1-oxo-2,3-dihydro-1H-isoindol-5-yloxymethyl)-benzonitrile 
• 252061-69-1 [5-(4-cyano-benzyloxy)-1-oxo-1,3-dihydro-isoindol-2-yl]-acetic acid tert-butyl ester 
• 252061-71-5 {5-[4-(tert-butoxycarbonylamino-imino-methyl)-benzyloxy]-1-oxo-1,3-dihydro-isoindol-2-yl}-acetic acid tert-butyl ester 
• 1263311-25-6 C₁₉H₁₉NO₄ 
• 1033809-83-4 5-(2-chloro-4-nitrophenoxy)-2,3-dihydro-1H-isoindol-1-one 
• 1033809-84-5 5-(4-amino-2-chlorophenoxy)-2,3-dihydro-1H-isoindol-1-one 
• 1410791-39-7 tert-butyl 3-benzyl-5-methoxy-1-oxoisoindoline-2-carboxylate 
• 1410791-40-0 3-benzyl-5-hydroxyisoindolin-1-one 
• 1410791-04-6 tert-butyl 2-(3-benzyl-1-oxoisoindolin-5-yloxy)ethylcarbamate 
• 1450608-38-4 3-benzyl-1-oxoisoindolin-5-yl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate 
• 1450608-39-5 3-benzyl-1-oxoisoindoline-5-carbonitrile 
• 1450608-40-8 5-(aminomethyl)-3-benzylisoindolin-1-one 
• 1410791-52-4 tert-butyl 1-benzyl-6-methoxy-1-methyl-3-oxoisoindoline-2-carboxylate 

Relevant articles and documents

Br?nsted Acid Catalyzed Dearomatization by Intramolecular Hydroalkoxylation/Claisen Rearrangement: Diastereo- and Enantioselective Synthesis of Spirolactams

Described herein is a novel Br?nsted acid catalyzed intramolecular hydroalkoxylation/Claisen rearrangement, allowing the practical and atom-economic synthesis of a range of valuable spirolactams from readily available ynamides in generally good to excellent yields with excellent diastereoselectivities and broad substrate scope. Importantly, an unexpected dearomatization of nonactivated arenes and heteroaromatic compounds is involved in this tandem sequence. Moreover, an asymmetric version of this tandem cyclization was also achieved by efficient kinetic resolution by chiral phosphoric acid catalysis. In addition, the [3,3]-rearrangement is shown to be kinetically preferred over the related [1,3]-rearrangement by theoretical calculations.

COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS

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Palladium-Catalyzed Direct C-H Carbonylation of Free Primary Benzylamines: A Synthesis of Benzolactams

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