22246-76-0 Usage
General Description
8-AMINO-1,3,4,5-TETRAHYDROBENZO[B]AZEPINE-2-ONE is a chemical compound that belongs to the class of tetrahydrobenzazepine derivatives. It is a heterocyclic compound with a benzene ring fused to a seven-membered ring containing one nitrogen atom. 8-AMINO-1,3,4,5-TETRAHYDROBENZO[B]AZEPINE-2-ONE is a potent inhibitor of the enzyme monoamine oxidase (MAO), which is involved in the metabolism of neurotransmitters such as dopamine, norepinephrine, and serotonin. As a result, it has potential applications in the treatment of neurological and psychiatric disorders such as depression and anxiety. Additionally, it may also have uses in the field of medicinal chemistry as a tool compound for researching the physiological and pathological roles of MAO.
Check Digit Verification of cas no
The CAS Registry Mumber 22246-76-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,2,4 and 6 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 22246-76:
(7*2)+(6*2)+(5*2)+(4*4)+(3*6)+(2*7)+(1*6)=90
90 % 10 = 0
So 22246-76-0 is a valid CAS Registry Number.
InChI:InChI=1/C10H12N2O/c11-8-5-4-7-2-1-3-10(13)12-9(7)6-8/h4-6H,1-3,11H2,(H,12,13)
22246-76-0Relevant articles and documents
Fused bicyclic derivatives of 2,4-diaminopyrimidine as c-Met inhibitors
Weinberg, Linda R.,Albom, Mark S.,Angeles, Thelma S.,Husten, Jean,Lisko, Joseph G.,McHugh, Robert J.,Milkiewicz, Karen L.,Murthy, Seetha,Ott, Gregory R.,Theroff, Jay P.,Tripathy, Rabindranath,Underiner, Ted L.,Zificsak, Craig A.,Dorsey, Bruce D.
scheme or table, p. 164 - 167 (2011/03/17)
The HGF-c-Met signaling axis is an important paracrine mediator of epithelial-mesenchymal cell interactions involving the regulation of multiple cellular activities including cell motility, mitogenesis, morphogenesis, and angiogenesis. Dysregulation of c-Met signaling (e.g., overexpression or increased activation) is associated with the development of a wide range of tumor types; thus, inhibiting the HGF-c-Met pathway is predicted to lead to anti-tumor effects in many cancers. Elaboration of a 2-arylaminopyrimidine scaffold led to a series of potent c-Met inhibitors bearing a C4-2-amino-N-methylbenzamide group. Specifically, a series of C2-benzazepinone analogs demonstrated potent inhibition of c-Met in enzymatic and cellular assays. Kinase selectivity could be tuned by varying the nature of the alkyl group on the benzazepinone nitrogen.
