22259-53-6 Usage
Description
(1H-INDOL-3-YL)METHANAMINE, also known as an indolic Tryptophan-derived metabolite, is an aralkylamino compound that features an indole group substituted at position 3 by an aminomethyl group. (1H-INDOL-3-YL)METHANAMINE is characterized by its antifungal defense properties, particularly against the Arabidopsis mlo2 mutant.
Uses
Used in Agricultural Applications:
(1H-INDOL-3-YL)METHANAMINE is used as an antifungal agent for protecting plants against fungal infections, specifically in the context of the Arabidopsis mlo2 mutant. Its application helps in enhancing the plant's defense mechanisms and reducing the impact of fungal diseases on crop yields and quality.
Used in Pharmaceutical Research:
(1H-INDOL-3-YL)METHANAMINE is used as a chemical compound in the research and development of new drugs, particularly those targeting fungal infections. Its unique structure and properties make it a promising candidate for the creation of novel antifungal medications.
Used in Chemical Synthesis:
(1H-INDOL-3-YL)METHANAMINE serves as a key intermediate in the synthesis of various organic compounds, including those with potential applications in the pharmaceutical, agrochemical, and materials science industries. Its versatile structure allows for further functionalization and modification to create a range of derivative compounds with specific applications.
Synthesis Reference(s)
Tetrahedron, 61, p. 9257, 2005 DOI: 10.1016/j.tet.2005.07.068
Check Digit Verification of cas no
The CAS Registry Mumber 22259-53-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,2,5 and 9 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 22259-53:
(7*2)+(6*2)+(5*2)+(4*5)+(3*9)+(2*5)+(1*3)=96
96 % 10 = 6
So 22259-53-6 is a valid CAS Registry Number.
InChI:InChI=1/C9H10N2/c10-5-7-6-11-9-4-2-1-3-8(7)9/h1-4,6,11H,5,10H2
22259-53-6Relevant articles and documents
An alternative approach to the synthesis of anticancer molecule spirobrassinin and its 2′-amino analogues
Budovská, Mariana,Tischlerová, Viera,Moj?i?, Ján,Kozlov, Oleksandr,Gondová, Ta?ána
, p. 63 - 77 (2020)
Abstract: A convenient synthesis of the cruciferous phytoalexin (S)-(?)-spirobrassinin and its (±)-2′-amino analogues have been achieved. Our synthetic route towards (S)-(?)-spirobrassinin is based on the CrO3-mediated cyclization of chiral 1-(2′,3′,4′,6′-tetra-O-acetyl-?-D-glucopyranosyl)brassinin and subsequent removal of the chiral auxiliary. (±)-2′-Amino analogues of spirobrassinin and 1-methoxyspirobrassinin were obtained from thioureas in one step in an efficient manner with the aid of CrO3. New synthesized compounds were screened in vitro for antiproliferative/cytotoxic activity against six human cancer cell lines by MTT assay. Amino analogues with CF3 functionality displayed good antiproliferative effect. Graphic abstract: [Figure not available: see fulltext.].
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Gower,Leete
, p. 3683 (1963)
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SELECTIVE INHIBITORS OF CLINICALLY IMPORTANT MUTANTS OF THE EGFR TYROSINE KINASE
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Page/Page column 256, (2017/08/01)
The present invention provides compounds of Formula (I) or a subgeneric structure or species thereof, or a pharmaceutically acceptable salt, ester, solvate, and/or prodrug thereof, and methods and compositions for treating or ameliorating abnormal cell proliferative disorders, such as cancer, wherein A, R2, R3, R10, E1, E2, E3, Y, and Z are as defined herein.
