222631-79-0

Basic information

• Product Name: 7H-Pyrazolo4,3-dpyrimidin-7-one, 1,4-dihydro-3-(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-
• Synonyms: 7H-Pyrazolo4,3-dpyrimidin-7-one, 1,4-dihydro-3-(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-
• CAS NO: 222631-79-0
• Molecular Formula: C10H13 N5 O3
• Molecular Weight: 251.24
• Mol File: 222631-79-0.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 7H-Pyrazolo4,3-dpyrimidin-7-one, 1,4-dihydro-3-(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 7H-Pyrazolo4,3-dpyrimidin-7-one, 1,4-dihydro-3-(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-(222631-79-0)
• EPA Substance Registry System: 7H-Pyrazolo4,3-dpyrimidin-7-one, 1,4-dihydro-3-(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-(222631-79-0)

Safety Data

• Hazardous Substances Data: 222631-79-0(Hazardous Substances Data)

Relevant articles and documents

Inhibitors of nucleoside metabolism

The present invention provides compounds having the formula: wherein A is CH or N; B is chosen from OH, NH2, NHR, H or halogen; D is chosen from OH, NH2, NHR, H, halogen or SCH3; R is an optionally substituted alkyl, aralkyl or aryl group; and X and Y are independently selected from H, OH or halogen except that when one of X and Y is hydroxy or halogen, the other is hydrogen; and Z is OH or, when X is hydroxy, Z is selected from hydrogen, halogen, hydroxy, SQ or OQ, Q is an optionally substituted alkyl, aralkyl or aryl group; or a tautomer thereof; or a pharmaceutically acceptable salt thereof; or an ester thereof; or a prodrug thereof; and compounds having the formula: wherein A, X, Y, Z and R are defined for compounds of formula (I) where first shown above; E is chosen from CO2H or a corresponding salt form, CO2R, CN, CONH2, CONHR or CONR2; and G is chosen from NH2, NHCOR, NHCONHR or NHCSNHR; or a tautomer thereof, or a pharmaceutically acceptable salt thereof, or an ester thereof, or a prodrug thereof. The present invention also provides the use of the above compounds as pharmaceuticals, pharmaceutical compositions containing the compounds and processes for preparing the compounds.