22276-16-0

Basic information

• Product Name: Benzenecarboximidamide, 3,4-dichloro-N-hydroxy-
• CAS NO: 22276-16-0
• Molecular Formula: C7H6Cl2N2O
• Molecular Weight: 205.043
• Mol File: 22276-16-0.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Benzenecarboximidamide, 3,4-dichloro-N-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenecarboximidamide, 3,4-dichloro-N-hydroxy-(22276-16-0)
• EPA Substance Registry System: Benzenecarboximidamide, 3,4-dichloro-N-hydroxy-(22276-16-0)

Safety Data

• Hazardous Substances Data: 22276-16-0(Hazardous Substances Data)

Upstream product

• 6287-38-3 3,4-dichlorobenzaldehyde 
• 6574-99-8 3,4-dichloro-benzonitrile 

Downstream Products

• 1429217-29-7 tert-butyl 4-(3-(3,4-dichlorophenyl)-1,2,4-oxadiazol-5-yl)butylcarbamate 
• 1429217-25-3 4-(3-(3,4-dichlorophenyl)-1,2,4-oxadiazol-5-yl)butan-1-amine 
• 72111-10-5 2-[3-(3,4-Dichlorophenyl)-1,2,4-Oxadiazol-5-yl]Benzoic Acid 
• 721428-40-6 3-(3,4-dichlorophenyl)-5-(bromomethyl)-1,2,4-oxadiazole 
• 110704-46-6 5-chloromethyl-3-(3,4-dichloro-phenyl)-[1,2,4]oxadiazole 

Relevant articles and documents

Discovery of 1,2,4-oxadiazole derivatives as a novel class of noncompetitive inhibitors of 3-hydroxykynurenine transaminase (HKT) from Aedes aegypti

The mosquito Aedes aegypti is the vector of arboviruses such as Zika, Chikungunya, dengue and yellow fever. These infectious diseases have a major impact on public health. The unavailability of effective vaccines or drugs to prevent or treat most of these

PYRIDINEDIONE CARBOXAMIDE INHIBITORS OF ENDOTHELIAL LIPASE

The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.

Discovery and structure-activity relationship of 3-aryl-5-aryl-1,2,4- oxadiazoles as a new series of apoptosis inducers and potential anticancer agents

We have identified 5-(3-chlorothiophen-2-yl)-3-(4-trifluoromethylphenyl)-1, 2,4-oxadiazole (1d) as a novel apoptosis inducer through our caspase- and cell-based high-throughput screening assay. Compound 1d has good activity against several breast and colorectal cancer cell lines but is inactive against several other cancer cell lines. In a flow cytometry assay, treatment of T47D cells with 1d resulted in arrest of cells in the G1 phase, followed by induction of apoptosis. SAR studies of Id showed that the 3-phenyl group can be replaced by a pyridyl group, and a substituted five-member ring in the 5-position is important for activity. 5-(3-Chlorothiophen-2-yl)-3-(5- chloropyridin-2-yl)-1,2,4-oxadiazole (41) has been found to have in vivo activity in a MX-1 tumor model. Using a photoaffinity agent, the molecular target has been identified as TIP47, an IGFII receptor binding protein. Therefore, our cell-based chemical genetics approach for the discovery of apoptosis inducers can identify potential anticancer agents as well as their molecular targets.