22282-72-0 Usage
Description
2-Hydroxyisonicotinic acid, also known as 2-Hydroxy-4-pyridone, is an organic compound with the chemical formula C5H4NO3. It is a white powder and is a derivative of isonicotinic acid, featuring a hydroxyl group at the 2nd position. 2-Hydroxyisonicotinic acid has been identified for its potential applications in various fields due to its unique chemical properties.
Uses
Used in Pharmaceutical Industry:
2-Hydroxyisonicotinic acid is used as a key intermediate in the synthesis of selective inhibitors of neuropeptide Y Y5, which play a crucial role in inhibiting food intake. This application is particularly relevant in the development of drugs for obesity and related metabolic disorders, as it targets the regulation of appetite and energy balance.
Used in HIV Treatment:
In the field of HIV research and treatment, 2-Hydroxyisonicotinic acid is utilized in the optimization of p-subsite residues of HIV protease inhibitors. These inhibitors are essential in the development of antiretroviral drugs, as they help to prevent the replication of the virus by blocking the action of HIV protease, a key enzyme in the viral replication process.
These applications highlight the versatility and potential of 2-Hydroxyisonicotinic acid in contributing to advancements in pharmaceutical research and drug development. Its unique chemical properties make it a valuable compound for further exploration and innovation in various industries.
Synthesis Reference(s)
Tetrahedron Letters, 29, p. 4389, 1988 DOI: 10.1016/S0040-4039(00)80502-X
Check Digit Verification of cas no
The CAS Registry Mumber 22282-72-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,2,8 and 2 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 22282-72:
(7*2)+(6*2)+(5*2)+(4*8)+(3*2)+(2*7)+(1*2)=90
90 % 10 = 0
So 22282-72-0 is a valid CAS Registry Number.
22282-72-0Relevant articles and documents
PROCESS FOR PRODUCTION OF 2-HYDROXY-4-SUBSTITUTED PYRIDINES
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Page/Page column 9-10, (2008/06/13)
A process for preparing a 2-hydroxy-4-substituted pyridine compound using a microbiological method, a novel microorganism, and a novel compound are provided. According to the process, a function of a microorganism or a product obtained therefrom is exerted on a 4-substituted pyridine of the general formula (1): wherein R is a methyl group, a carboxyl group, a carbamoyl group, a hydroxyiminomethyl group or a cyano group, to obtain the corresponding 2-hydroxy-4-substituted pyridine compound. The novel microorganisms are the Delftia species YGK-A649 (FERM BP-10389), Delftia species YGK-C217 (FERM BP-10388), or Acidovorax species YGK-A854 (FERM BP-10387) and the novel compound is a 2-hydroxy-4-pyridinaldoxime.
