22282-73-1

Basic information

• Product Name: 3-FLUORO-4-HYDROXYPYRIDINE
• Synonyms: 3-FLUORO-4-HYDROXYPYRIDINE;3-FLUORO-4-PYRIDINOL;3-Fluoro-4-hydroxypyridine97%;3-FLUORO-4-HYDROXYPYRIDINE 97%;3-Fluoropyridin-4-ol;3-fluoropyridin-4(1H)-one
• CAS NO: 22282-73-1
• Molecular Formula: C₅H₄FNO
• Molecular Weight: 113.09
• Product Categories: Pyridines
• Mol File: 22282-73-1.mol
• Article Data: 2

Chemical Properties

• Melting Point: 153 °C
• Boiling Point: 175.5 °C at 760 mmHg
• Flash Point: 59.9 °C
• Appearance: /
• Density: 1.26g/cm³
• Vapor Pressure: 1.14mmHg at 25°C
• Refractive Index: 1.508
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.99±0.18(Predicted)
• CAS DataBase Reference: 3-FLUORO-4-HYDROXYPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-FLUORO-4-HYDROXYPYRIDINE(22282-73-1)
• EPA Substance Registry System: 3-FLUORO-4-HYDROXYPYRIDINE(22282-73-1)

Safety Data

• Hazardous Substances Data: 22282-73-1(Hazardous Substances Data)

Usage

General Description

3-Fluoro-4-hydroxypyridine is a chemical compound with the molecular formula C5H4FNO. It is a fluorinated pyridine derivative that contains a hydroxyl group. This chemical is commonly used as a building block in the synthesis of pharmaceuticals and agrochemicals. It is also used in chemical research and industrial processes. 3-Fluoro-4-hydroxypyridine has potential applications in the development of new drugs and crop protection products due to its unique chemical properties. It is important to handle this chemical with care and follow proper safety precautions due to its potentially hazardous nature.

InChI:InChI=1/C5H4FNO/c6-4-3-7-2-1-5(4)8/h1-3H,(H,7,8)

Upstream product

• 458532-97-3 3-fluoro-4-pyridylboronic acid 

Downstream Products

• 955029-44-4 (syn)-3-fluoro-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester 
• 1390657-64-3 tert-butyl 4-(4-((7-((3-fluoropyridin-4-yl)oxy)-4-oxo-3,4-dihydropyrido[3,4-d]pyridazin-5-yl)amino)-3-methoxyphenyl)piperazine-1-carboxylate 

Relevant articles and documents

Oxidative hydroxylation of arylboronic acids to phenols catalyzed by copper nanoparticles ellagic acid composite

Copper nanoparticles (Cu NPs) were prepared by in situ reduction of CuSO4·5H2O using ellagic acid (EA) as the reducing agent as well as stabilizer and its catalytic activity is tested in the oxidative hydroxylation of phenylboronic acids to phenol without any added base or ligand. The synthesized Cu NPs-EA composite was characterized by UV-Vis., FT-IR, powder XRD and HRTEM analyses. The average particle size of Cu NPs is found to be in the range of 20-25 nm as evident from HRTEM and copper content is estimated to be 3.18 wt%. EA acts both as a reducing agent as well as a stabilizer for the in situ formation of Cu NPs. A small portion of Cu NPs is also found to undergo aerobic oxidation to give Cu2O NPs which does not take part in the reactions. A series of arylboronic acids are converted to the corresponding phenols in high yields at short reaction time under milder reaction conditions. It is also observed that Cu NPs-EA composite can be reused at least four times with a significant decrease in the yield.