222843-51-8Relevant articles and documents
Synthesis of Fmoc-protected 4-carboxydifluoromethyl-L-phenylalanine: A phosphotyrosyl mimetic of potential use for signal transduction studies
Yao, Zhu-Jun,Gao, Yang,Voigt, Johannes H.,Ford Jr., Harry,Burke Jr., Terrence R.
, p. 2865 - 2874 (1999)
4-(Carboxymethyl)phenylalanine (2) and its α,α-difluoro homologue 4- (carboxydifluoromethyl)-phenylalanine (3) have been described as phosphotyrosyl mimetics. Herein we report the synthesis of N-Fmoc 4-(O-tert- butyl carboxymethyl)phenylalanine (4) and N-