222961-71-9Relevant articles and documents
S(N)Ar reactions of 2-haloarylsulfoxides with alkoxides provide a novel synthesis of thiotomoxetine
Ratz, Andrew M.,Weigel, Leland O.
, p. 2239 - 2242 (2007/10/03)
A five step synthesis of thiotomoxetine (2) is described. Installation of the aryl ether was accomplished using a highly efficient S(N)Ar fragment coupling between amino alcohol (4) and a 1-halo-2-methylsulfinylbenzene (X = F or Cl) followed by a selective reduction of the arylsulfoxide moiety.