222978-01-0

Basic information

• Product Name: (4-BROMO-3-FLUOROPHENYL)METHANOL
• Synonyms: (4-BROMO-3-FLUOROPHENYL)METHANOL;4-Bromo-3-fluorobenzenemethanol;BenzeneMethanol, 4-broMo-3-fluoro-
• CAS NO: 222978-01-0
• Molecular Formula: C₇H₆BrFO
• Molecular Weight: 205.02
• Mol File: 222978-01-0.mol
• Article Data: 41

Chemical Properties

• Melting Point: 44.0 to 48.0 °C
• Boiling Point: 260℃
• Flash Point: 111℃
• Appearance: /
• Density: 1.658
• Vapor Pressure: 0.00645mmHg at 25°C
• Refractive Index: 1.566
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 13.70±0.10(Predicted)
• CAS DataBase Reference: (4-BROMO-3-FLUOROPHENYL)METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (4-BROMO-3-FLUOROPHENYL)METHANOL(222978-01-0)
• EPA Substance Registry System: (4-BROMO-3-FLUOROPHENYL)METHANOL(222978-01-0)

Safety Data

• Hazardous Substances Data: 222978-01-0(Hazardous Substances Data)

Usage

General Description

(4-Bromo-3-fluorophenyl)methanol is a chemical compound that contains a benzene ring with a bromine atom in the 4-position and a fluorine atom in the 3-position, connected to a methanol group. It is used as a versatile building block in organic synthesis, particularly in the pharmaceutical industry. (4-Bromo-3-fluorophenyl)methanol has potential applications as a building block for the synthesis of various biologically active molecules, including pharmaceuticals and agrochemicals. Additionally, it has been studied for its antimicrobial and antifungal properties, making it a versatile and valuable chemical in various industries. Overall, the compound has a wide range of potential applications due to its unique structure and chemical properties.

InChI:InChI=1/C7H6BrFO/c8-6-2-1-5(4-10)3-7(6)9/h1-3,10H,4H2

Upstream product

• 153556-42-4 4-bromo-3-fluorobenzoic acid 
• 452-74-4 4-bromo-3-fluorotoluene 
• 133059-43-5 4-bromo-3-fluorobenzaldehyde 
• 849758-12-9 methyl 4-bromo-3-fluorobenzoate 
• 127425-73-4 1-bromo-4-(bromomethyl)-2-fluorobenzene 

Downstream Products

• 222978-02-1 2-fluoro-4-(hydroxymethyl)benzonitrile 
• 1009334-17-1 (4-bromo-3-fluoro-benzyloxy)-triisopropyl-silane 
• 222978-03-2 4-cyano-3-fluorobenzylbromide 
• 101048-76-4 4-cyano-3-fluorobenzaldehyde 
• 222978-26-9 2-Fluoro-4-[hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-benzonitrile 
• 222978-28-1 2-fluoro-4-(1-methyl-1H-imidazole-5-carbonyl)benzonitrile 
• 275807-76-6 2-fluoro-4-[amino-(1-methyl-1H-imidazol-5-yl)methyl]benzonitrile 
• 222978-25-8 acetic acid (4-cyano-3-fluorophenyl)(3-methyl-3H-imidazol-4-yl)methyl ester 
• 403825-23-0 1-(S)-N-[1-(4-cyano-3-fluorophenyl)-1-(3-methyl-3H-imidazol-4-yl)ethyl]-2-methyl-[S(R)]-propanesulfinamide 
• 275807-74-4 2-fluoro-4-(1-trityl-1H-imidazol-4-ylmethyl)benzonitrile 
• 275806-03-6 2-[3-(3-ethyl-azepan-3-yl)-phenoxy]-4-imidazol-1-ylmethyl-benzonitrile 
• 222978-23-6 2-Fluoro-4-[hydroxy-(1-trityl-1H-imidazol-4-yl)-methyl]-benzonitrile 
• 222978-24-7 acetic acid (4-cyano-3-fluorophenyl)(1-trityl-1H-imidazol-4-yl)methyl ester 

Relevant articles and documents

METHODS OF TREATING HEMATOLOGICAL MALIGNANCIES USING 2-(2,6-DIOXOPIPERIDIN-3-YL)-4-((2-FLUORO-4-((3-MORPHOLINOAZETIDIN-1-YL)METHYL)BENZYL)AMINO)ISOINDOLINE-1,3-DIONE

Provided herein are methods of using 2-(2,6-dioxopiperidin-3-yl)-4-((2-fluoro-4-((3-morpholinoazetidin-1-yl)methyl)benzyl)amino)isoindoline-1,3-dione, or an enantiomer, a mixture of enantiomers, a tautomer, an isotopolog, or a pharmaceutically acceptable salt thereof, for treating, preventing or managing hematological malignancies.

METHODS OF TREATING NON-HODGKIN LYMPHOMA USING 2-(2,6-DIOXOPIPERIDIN-3-YL)-4-((2-FLUORO-4-((3-MORPHOLINOAZETIDIN-1-YL)METHYL)BENZYL)AMINO)ISOINDOLINE-1,3-DIONE

Provided herein are methods of using 2-(2,6-dioxopiperidin-3-yl)-4-((2-fluoro-4-((3-morpholinoazetidin-1-yl)methyl)benzyl)amino)isoindoline-1,3-dione, or an enantiomer, a mixture of enantiomers, a tautomer, an isotopolog, or a pharmaceutically acceptable salt thereof, alone or in combination with rituximab, for treating, preventing or managing non-Hodgkin lymphoma.

SUBSTITUTED 4-AMINOISOINDOLINE-1,3-DIONE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH

Provided herein are 4-aminoisoindoline-1,3-dione compounds having the following structure: wherein R, Ring A, and n are as defined herein, compositions comprising an effective amount of a 4-aminoisoindoline-1,3-dione compound, and methods for treating or preventing disorders.