223259-26-5 Usage
Description
(5Z,8Z,11Z,14Z)-2-[[Tris(1-Methylethyl)silyl]oxy]-5,8,11,14-eicosatetraenoic Acid 1-[[[Tris(1-Methylethyl)silyl]oxy]Methyl]ethyl Ester is a complex organic compound with a unique structure that features multiple double bonds and a tris(1-methylethyl)silyl group. (5Z,8Z,11Z,14Z)-2-[[Tris(1-Methylethyl)silyl]oxy]-5,8,11,14-eicosatetraenoic Acid 1-[[[Tris(1-Methylethyl)silyl]oxy]Methyl]ethyl Ester serves as an intermediate in the synthesis of biologically active molecules, specifically in the production of 2-Arachidonoylglycerol (A765050), a major endocannabinoid.
Uses
Used in Pharmaceutical Industry:
(5Z,8Z,11Z,14Z)-2-[[Tris(1-Methylethyl)silyl]oxy]-5,8,11,14-eicosatetraenoic Acid 1-[[[Tris(1-Methylethyl)silyl]oxy]Methyl]ethyl Ester is used as an intermediate in the synthesis of 2-Arachidonoylglycerol (A765050) for its role in modulating synaptic transmission. The compound acts as an inhibitor of presynaptic cannabinoid CB1 receptors, which can have potential therapeutic applications in various conditions related to the endocannabinoid system.
Used in Research and Development:
In the field of research and development, this compound is utilized as a key component in the synthesis of endocannabinoids and other related molecules. It can be employed in the study of the endocannabinoid system's role in various physiological processes and the development of novel therapeutic agents targeting this system.
Used in Drug Synthesis:
(5Z,8Z,11Z,14Z)-2-[[Tris(1-Methylethyl)silyl]oxy]-5,8,11,14-eicosatetraenoic Acid 1-[[[Tris(1-Methylethyl)silyl]oxy]Methyl]ethyl Ester is used as a precursor in the synthesis of various pharmaceutical compounds, particularly those targeting the endocannabinoid system. Its unique structure and functional groups make it a valuable building block for the development of new drugs with potential applications in treating a range of conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 223259-26-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,3,2,5 and 9 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 223259-26:
(8*2)+(7*2)+(6*3)+(5*2)+(4*5)+(3*9)+(2*2)+(1*6)=115
115 % 10 = 5
So 223259-26-5 is a valid CAS Registry Number.
223259-26-5Relevant articles and documents
Total synthesis of 2-arachidonylglycerol (2-Ara-Gl)
Han, Luning,Razdan, Raj K.
, p. 1631 - 1634 (2007/10/03)
Total synthesis of 2-Arachidonylglycerol (2-Ara-Gl) was accomplished starting from arachidonic acid and glycerol. The sequence involves selective protection of the primary alcohols of glycerol, esterification, and mild hydrolysis of the protecting groups. A unique hydrolysis condition was developed to prevent isomerization of the 2-Ara-Gl to the more stable 1- monoglyceride.
