22339-62-4

Basic information

• Product Name: 4-[4-(3-carboxypropyl)phenyl]butyric acid
• Synonyms: 4-[4-(3-carboxypropyl)phenyl]butyric acid
• CAS NO: 22339-62-4
• Molecular Weight: 250.295
• Mol File: 22339-62-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-[4-(3-carboxypropyl)phenyl]butyric acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[4-(3-carboxypropyl)phenyl]butyric acid(22339-62-4)
• EPA Substance Registry System: 4-[4-(3-carboxypropyl)phenyl]butyric acid(22339-62-4)

Safety Data

• Hazardous Substances Data: 22339-62-4(Hazardous Substances Data)

Upstream product

• 4251-21-2 3,3'-(1,4-phenylene)dipropanoic acid 
• 19417-59-5 1,4-bis-(3-bromopropyl)-benzene 
• 19417-58-4 [1,4-phenylene]-bis(3-hydroxypropane) 
• 96-48-0 4-butanolide 
• 7446-70-0 aluminium trichloride 
• 71-43-2 benzene 
• 85784-82-3 1,4-bis(4-cyanopropyl)benzene 
• 22339-61-3 γ-(p-succinylphenyl)butyric acid 
• 4542-72-7 1,4-bis-(2-bromoethyl)benzene 
• 5140-03-4 2-[4-(2-hydroxyethyl)phenyl]ethan-1-ol 
• 623-27-8 terephthalaldehyde, 
• 16323-43-6 1,4-phenylenediacrylic acid 

Downstream Products

• 144582-02-5 C₂₆H₃₆N₂ 
• 144582-14-9 4-[4-(3-Carboxy-propyl)-2-nitro-phenyl]-butyric acid 
• 144582-13-8 4-[4-(3-Ethoxycarbonyl-propyl)-2-nitro-phenyl]-butyric acid ethyl ester 
• 144582-03-6 1,4-Bis<4-(5-formyl-2,4-dimethylpyrrol-3-yl)butyl>benzene 
• 144582-29-6 N-{2,5-Bis-[4-(2,4-dimethyl-1H-pyrrol-3-yl)-butyl]-phenyl}-acetamide 
• 144582-01-4 C₂₈H₃₆N₂O₄ 
• 144582-32-1 N-{2,5-Bis-[4-(5-formyl-2,4-dimethyl-1H-pyrrol-3-yl)-butyl]-phenyl}-acetamide 
• 144581-96-4 1,4-Bis<4-(5-ethoxycarbonyl-2,4-dimethylpyrrol-3-yl)butyl>benzene 
• 144582-26-3 C₃₀H₃₉N₃O₅ 
• 144581-95-3 1,4-Bis<4-(5-ethoxycarbonyl-2,4-dimethylpyrrol-3-yl)-4-oxobutyl>benzene 
• 144581-97-5 1,4-Bis<4-(5-ethoxycarbonyl-2,4-dimethylpyrrol-3-yl)butyl>-2-nitrobenzene 
• 144581-98-6 1,4-Bis<4-(5-ethoxycarbonyl-2,4-dimethylpyrrol-3-yl)butyl>-2-acetamidobenzene 
• 144582-18-3 C₃₂H₃₉N₃O₈ 
• 144581-99-7 1,4-Bis<4-(5-benzyloxycarbonyl-2,4-dimethylpyrrol-3-yl)butyl>benzene 

Relevant articles and documents

FUNCTIONALIZED LONG-CHAIN HYDROCARBON MONO- AND DI-CARBOXYLIC ACIDS AND THEIR USE FOR THE PREVENTION OR TREATMENT OF DISEASE

This invention provides compounds of Formulae (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH), (IJ), (IK), (IL), (II), (III), (IIIA), and (IIIB); pharmaceutically acceptable salts and solvates thereof; and compositions thereof. This invention further provides methods for treating a disease, including but not limited to, liver disease or an abnormal liver condition; cancer (such as hepatocellular carcinoma or cholangiocarcinoma); a malignant or benign tumor of the lung, liver, gall bladder, bile duct or digestive tract; an intra- or extra-hepatic bile duct disease; a disorder of lipoprotein; a lipid-and-metabolic disorder; cirrhosis; fibrosis; a disorder of glucose metabolism; a cardiovascular or related vascular disorder; a disease resulting from steatosis, fibrosis, or cirrhosis; a disease associated with increased inflammation (such as hepatic inflammation or pulmonary inflammation); hepatocyte ballooning; a peroxisome proliferator activated receptor-associated disorder; an ATP citrate lyase disorder; an acetyl-coenzyme A carboxylase disorder; obesity; pancreatitis; or renal disease.

Synthesis and characterization of derivatized capped porhyrins

The syntheses of porphyrins carrying either a fully hydrophobic cavity with a benzene moiety (32a,b) or a polar cavity with an amidobenzene (32c-d) are described.Terephthaldehyde (1) was converted to benzene-bisalkanoic acids (8, 10) and nitrobenzene-bisalkanoic acids (13 and 16) by using standard methods.The corresponding diacid chlorides 17a-d were used to acylate two equivalents of a β-unsubstituted pyrrole, and the ketonic groups were reduced by diborane.Following the transformation of the nitro function to the acetamide, appropriate modifications of the ethyl ester functions afforded the key bisformylpyrroles 25a-d.The cyanoacrylate-protected formyl pyrrole derivatives were monochlorinated at the α-methyl groups and condensed with two equivalents of an α-unsubstituted pyrrole to give the dipyrromethane dimers.Strong aqueous alkali caused saponification of the two ester groups and deprotection of the formyl functions to produce the dipyrromethane dimer 30, which, after thermal decarboxylation, was cyclized intramolecularly in acidic medium to give the porphyrins 32 (n = 4 or 5, X = H or NHCOCH3).