223400-50-8

Basic information

• Product Name: (4R,5S)-5-hydroxy-1-(2-methoxyphenyl)-4-(D-arabino-tetritol-1-yl)imidazolidine-2-thione
• Synonyms: (4R,5S)-5-hydroxy-1-(2-methoxyphenyl)-4-(D-arabino-tetritol-1-yl)imidazolidine-2-thione
• CAS NO: 223400-50-8
• Molecular Weight: 344.389
• Mol File: 223400-50-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (4R,5S)-5-hydroxy-1-(2-methoxyphenyl)-4-(D-arabino-tetritol-1-yl)imidazolidine-2-thione(CAS DataBase Reference)
• NIST Chemistry Reference: (4R,5S)-5-hydroxy-1-(2-methoxyphenyl)-4-(D-arabino-tetritol-1-yl)imidazolidine-2-thione(223400-50-8)
• EPA Substance Registry System: (4R,5S)-5-hydroxy-1-(2-methoxyphenyl)-4-(D-arabino-tetritol-1-yl)imidazolidine-2-thione(223400-50-8)

Safety Data

• Hazardous Substances Data: 223400-50-8(Hazardous Substances Data)

Upstream product

• 1078691-95-8 (+)-D-glucosamine hydrochloride 
• 3288-04-8 1-isothiocyanato-2-methoxybenzene 

Relevant articles and documents

Non-biaryl atropisomers derived from carbohydrates. Part 1. Stereoselective synthesis of 1-aryl-5-hydroxyimidazolidine-2-thiones and their transformation into imidazoline-2-thiones

A series of chiral-5-hydroxyimidazolidine-2-thiones bearing an ortho- substituted aromatic residue at N-1, which are readily accessible from D- glucosamine, have been synthesized as potential atropisomers. In general, these substances display a trans arrangement between H-4 and H-5, and hence the absolute configuration at C-5 was shown to be R. However, the first example of this type of structures having a cis configuration (S at C-5) is also described. Moreover, the mechanistic features associated with the conversion of 5-acetoxyimidazolidine-2- thiones into imidazoline-2-thiones have also been evaluated.