22347-29-1 Usage
Description
1-(4-bromophenyl)-5-mercapto-1,2,3,4-tetrazole is a chemical compound with the molecular formula C7H5BrN4S. It is a tetrazole derivative known for its potential applications in the pharmaceutical and agricultural industries due to its pharmacological properties, which include antihypertensive, anticonvulsant, and antifungal activities. 1-(4-bromophenyl)-5-mercapto-1,2,3,4-tetrazole features a bromine atom and a thiol group, making it a versatile candidate for various chemical reactions and synthesis processes. Additionally, it may have potential use as a ligand in coordination chemistry and catalysis.
Uses
Used in Pharmaceutical Industry:
1-(4-bromophenyl)-5-mercapto-1,2,3,4-tetrazole is used as a chemical intermediate for the development of new drugs, leveraging its pharmacological properties such as antihypertensive, anticonvulsant, and antifungal activities. Its unique structure with a bromine atom and a thiol group allows for further chemical modifications and the creation of novel therapeutic agents.
Used in Agricultural Industry:
In the agricultural industry, 1-(4-bromophenyl)-5-mercapto-1,2,3,4-tetrazole is used as a building block for the synthesis of new agrochemicals, potentially offering enhanced pest control and crop protection solutions due to its antifungal properties.
Used in Coordination Chemistry and Catalysis:
1-(4-bromophenyl)-5-mercapto-1,2,3,4-tetrazole is used as a potential ligand in coordination chemistry and catalysis, where its bromine atom and thiol group can interact with metal ions to form stable complexes, potentially enhancing the efficiency of catalytic reactions.
Further research and testing are necessary to fully understand and exploit the potential applications of 1-(4-bromophenyl)-5-mercapto-1,2,3,4-tetrazole in these industries.
Check Digit Verification of cas no
The CAS Registry Mumber 22347-29-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,3,4 and 7 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 22347-29:
(7*2)+(6*2)+(5*3)+(4*4)+(3*7)+(2*2)+(1*9)=91
91 % 10 = 1
So 22347-29-1 is a valid CAS Registry Number.
InChI:InChI=1/C7H5BrN4S/c8-5-1-3-6(4-2-5)12-7(13)9-10-11-12/h1-4H,(H,9,11,13)
22347-29-1Relevant articles and documents
Discovery of quinazoline derivatives as a novel class of potent and in vivo efficacious LSD1 inhibitors by drug repurposing
Li, Zhonghua,Li, Zhongrui,Ma, Jinlian,Miao, Jinxin,Qin, Tingting,Yang, Nian,Zhang, Xinhui,Zhang, Zhenqiang,Zhao, Taoqian,Zhao, Xuan
, (2021/08/19)
Histone lysine-specific demethylase 1 (LSD1) is an important epigenetic modulator, and is implicated in malignant transformation and tumor pathogenesis in different ways. Therefore, the inhibition of LSD1 provides an attractive therapeutic target for cancer therapy. Based on drug repurposing strategy, we screened our in-house chemical library toward LSD1, and found that the EGFR inhibitor erlotinib, an FDA-approved drug for lung cancer, possessed low potency against LSD1 (IC50 = 35.80 μM). Herein, we report our further medicinal chemistry effort to obtain a highly water-soluble erlotinib analog 5k (>100 mg/mL) with significantly enhanced inhibitory activity against LSD1 (IC50 = 0.69 μM) as well as higher specificity. In MGC-803 cells, 5k suppressed the demethylation of LSD1, indicating its cellular activity against the enzyme. In addition, 5k had a remarkable capacity to inhibit colony formation, suppress migration and induce apoptosis of MGC803 cells. Furthermore, in MGC-803 xenograft mouse model, 5k treatment resulted in significant reduction in tumor size by 81.6% and 96.1% at dosages of 40 and 80 mg/kg/d, respectively. Our findings indicate that erlotinib-based analogs provide a novel structural set of LSD1 inhibitors with potential for further investigation, and may serve as novel candidates for the treatment of LSD1-overexpressing cancers.
