22352-82-5 Usage
Description
N-4-Piperidylacetanilide Hydrochloride, also known as Acetyl norfentanyl hydrochloride, is an analytical reference material that is structurally similar to known opioids. It is a metabolite of Acetyl Fentanyl (A175000), an analogue of fentanyl analog, and is primarily used for research and forensic applications.
Uses
Used in Pharmaceutical Research:
N-4-Piperidylacetanilide Hydrochloride is used as a research compound for understanding the structure and activity of opioids. Its structural similarity to known opioids makes it a valuable tool in the development of new drugs and therapies targeting the opioid system.
Used in Forensic Applications:
N-4-Piperidylacetanilide Hydrochloride is used as a forensic standard for the identification and quantification of opioids in biological samples. Its role in forensic analysis aids in the detection and investigation of drug-related crimes and overdose cases.
Used in Metabolite Studies:
As a metabolite of Acetyl Fentanyl, N-4-Piperidylacetanilide Hydrochloride is used in the study of the metabolic pathways and pharmacokinetics of fentanyl analogs. This information is crucial for understanding the behavior of these drugs in the body and their potential risks and side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 22352-82-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,3,5 and 2 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 22352-82:
(7*2)+(6*2)+(5*3)+(4*5)+(3*2)+(2*8)+(1*2)=85
85 % 10 = 5
So 22352-82-5 is a valid CAS Registry Number.
22352-82-5Relevant articles and documents
Quantitative measurement of acetyl fentanyl and acetyl norfentanyl in human urine by LC-MS/MS
Patton, Amy L.,Seely, Kathryn A.,Pulla, Sharon,Rusch, Nancy J.,Moran, Cindy L.,Fantegrossi, William E.,Knight, Laura D.,Marraffa, Jeanna M.,Kennedy, Paul D.,James, Laura P.,Endres, Gregory W.,Moran, Jeffery H.
, p. 1760 - 1766 (2014)
Opioid abuse involving emerging opioid compounds is a growing public health problem, which was highlighted recently by cases of human morbidity and mortality linked to acetyl fentanyl abuse. Unfortunately, the lack of information available on the toxicology and metabolism of acetyl fentanyl precludes its detection in human samples. The following study was conducted to test a new analytical procedure for the simultaneous quantification of acetyl fentanyl and its predicted metabolite, acetyl norfentanyl, in human urine. Metabolic reference standards and deuterium-labeled internal standards were synthesized for use in an assay that coupled solid-phase extraction (SPE) with liquid chromatography-tandem mass spectrometry (LC-MS/MS). The accuracy (% Relative Error 2 > 0.98). Preliminary human liver microsomal and in vivo rodent studies demonstrated that acetyl fentanyl is metabolized by cytochrome P450s to acetyl norfentanyl. Urine samples from rats treated with a toxic dose of acetyl fentanyl contained high concentrations of acetyl fentanyl and acetyl norfentanyl. Further toxicokinetic studies are required to fully elucidate the metabolic pathways responsible for acetyl fentanyl detoxification and excretion.