223526-67-8 Usage
Description
(αR)-α-[(3S)-3-(tert-ButyloxycarbonylaMino)-4-Methyl-2-oxopentyl]-4-fluoro-benzenepropanoic Acid is a complex organic compound characterized by its unique molecular structure. It is a chiral molecule with specific stereochemistry, which plays a crucial role in its biological activity and potential applications.
Uses
Used in Pharmaceutical Industry:
(αR)-α-[(3S)-3-(tert-ButyloxycarbonylaMino)-4-Methyl-2-oxopentyl]-4-fluoro-benzenepropanoic Acid is used as a key intermediate in the synthesis of rhinovirus protease inhibitors. These inhibitors are essential for the development of antiviral drugs targeting the human rhinovirus, which is a significant cause of the common cold and other respiratory illnesses.
Additionally, this compound is used as a building block in the preparation of peptidomimetic α,β-unsaturated esters. These esters have potential applications in the design and synthesis of novel peptide-based drugs, which can mimic the action of natural peptides with improved stability and bioavailability. This makes them valuable in the development of new therapeutic agents for various diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 223526-67-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,3,5,2 and 6 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 223526-67:
(8*2)+(7*2)+(6*3)+(5*5)+(4*2)+(3*6)+(2*6)+(1*7)=118
118 % 10 = 8
So 223526-67-8 is a valid CAS Registry Number.
223526-67-8Relevant articles and documents
Improved synthesis of rupintrivir
Lin, Daizong,Qian, Wangke,Hilgenfeld, Rolf,Jiang, Hualiang,Chen, Kaixian,Liu, Hong
, p. 1101 - 1107 (2012/09/08)
An improved synthesis of rupintrivir (AG7088) was accomplished using three amino acids (l-glutamic acid, d-4-fluorophenylalanine, and l-valine) as the building blocks. The key fragment ketomethylene dipeptide isostere was constructed with the valine derivative and phenylpropionic acid derivative, followed by coupling with a lactam derivative and an isoxazole acid chloride to provide AG7088 totally in eight steps.
An efficient and tunable route to AG7088, a rhinovirus protease inhibitor
Ma, Dawei,Xie, Weiqing,Zou, Bin,Lei, Qiong,Pei, Duanqing
, p. 8103 - 8105 (2007/10/03)
Aldol reaction of N,N-dibenzyl valinal with propiolic acid ethyl ester derived lithium reagent provides anti-aminoalcohol 8 and syn-aminoalcohol 9, which are converted into the lactone 6 via two different routes. Alkylation of 6 followed by lactone ring o
