22353-29-3

Basic information

• Product Name: 4-methyl-N'-(pyridin-2-ylmethylene)benzenesulfonohydrazide
• Synonyms: 4-methyl-N'-(pyridin-2-ylmethylene)benzenesulfonohydrazide
• CAS NO: 22353-29-3
• Molecular Weight: 275.331
• Mol File: 22353-29-3.mol
• Article Data: 12

Chemical Properties

• CAS DataBase Reference: 4-methyl-N'-(pyridin-2-ylmethylene)benzenesulfonohydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-N'-(pyridin-2-ylmethylene)benzenesulfonohydrazide(22353-29-3)
• EPA Substance Registry System: 4-methyl-N'-(pyridin-2-ylmethylene)benzenesulfonohydrazide(22353-29-3)

Safety Data

• Hazardous Substances Data: 22353-29-3(Hazardous Substances Data)

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 1121-60-4 pyridine-2-carbaldehyde 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 

Downstream Products

• 274-59-9 triazolopyridine 
• 58414-96-3 2-pyridylmethyl 4-tolyl sulfone 
• 1437-15-6 1,2-bis(2-pyridyl)ethylene 
• 1384956-02-8 (E)-7-(1,2-diphenylvinyl)-[1,2,3]triazolo[1,5-a]pyridine 
• 1384956-30-2 (E)-7-(2-D-1,2-diphenylvinyl)-[1,2,3]triazolo[1,5-a]pyridine 
• 1384956-12-0 (E)-7-(1,2-di(p-tolyl)vinyl)-[1,2,3]triazolo[1,5-a]pyridine 
• 1384956-17-5 C₁₅H₁₃N₃ 
• 1384956-16-4 (E)-7-(1-phenylprop-1-en-2-yl)-[1,2,3]triazolo[1,5-a]pyridine 
• 1384956-18-6 (E)-7-(1-p-tolylprop-1-en-2-yl)-[1,2,3]triazolo[1,5-a]pyridine 
• 1384956-19-7 C₁₆H₁₅N₃ 
• 1384956-20-0 (E)-7-(1-(4-methoxyphenyl)prop-1-en-2-yl)-[1,2,3]triazolo[1,5-a]pyridine 
• 1384956-21-1 C₁₆H₁₅N₃O 
• 1384956-22-2 (E)-7-(1-(4-fluorophenyl)prop-1-en-2-yl)-[1,2,3]triazolo[1,5-a]pyridine 
• 1384956-23-3 C₁₅H₁₂FN₃ 

Relevant articles and documents

Synthesis and Evaluation of Novel Radioligands Based on 3-[5-(Pyridin-2-yl)-2H-tetrazol-2-yl]benzonitrile for Positron Emission Tomography Imaging of Metabotropic Glutamate Receptor Subtype 5

We found out 3-[5-(pyridin-2-yl)-2H-tetrazol-2-yl]benzonitrile analogues as the candidate for positron emission tomography (PET) imaging agents of metabotropic glutamate receptor subtype 5 (mGluR5). Among these compounds, 3-methyl-5-(5-(pyridin-2-yl)-2H-tetrazol-2-yl)benzonitrile (10) exhibited high binding affinity (Ki = 9.4 nM) and moderate lipophilicity (cLogD, 2.4). Subsequently, [11C]10 was radiosynthesized at 25 ± 14% radiochemical yield (n = 11) via C-[11C]methylation of the arylstannyl precursor 15 with [11C]methyl iodide. In vitro autoradiography and PET assessments using [11C]10 showed high specific binding in the striatum and hippocampus, two brain regions enriched with mGluR5. Moreover, test-retest PET studies with [11C]10 indicated high reliability to quantify mGluR5 density, such as the intraclass correlation coefficient (0.90) and Pearson r (0.91) in the striatum of rat brain. We demonstrated that [11C]10 is a useful PET ligand for imaging and quantitative analysis of mGluR5. Furthermore, [11C]10 might be modified using its skeleton as a lead compound.

Diversity-Oriented Synthesis of 1,2,4-Triazols, 1,3,4-Thiadiazols, and 1,3,4-Selenadiazoles from N-Tosylhydrazones

The diversity-oriented synthesis of 1,2,4-triazols, 1,3,4-thiadiazols, and 1,3,4-selenadiazoles from N-tosylhydrazones was developed, and the reactions were general for a wide range of substrates, in which NH2CN, KOCN, KSCN, and KSeCN were used as odorless sources. Two different pathways were proposed, and N-tosylhydrazonoyl chlorides were formed in situ in the presence of NCS.

Iron Hydride Radical Reductive Alkylation of Unactivated Alkenes

Iron-catalyzed hydrogen atom transfer-mediated intermolecular C-C coupling reactions between alkenes and tosylhydrazones, followed by in situ cleavage of the tosylhydrazine intermediates using Et3N, are described. The process involves a new strategic bond disconnection resulting in the reductive alkylation of nonactivated alkenes. The reaction is operationally simple, proceeds under mild conditions, and has a wide substrate scope.