22353-46-4 Usage
Description
(5-Chloro-3-nitro-pyridin-2-yl)-hydrazine is a chemical compound characterized by a pyridine ring with a chlorine atom at the 5th position and a nitro group at the 3rd position. It features a hydrazine functional group attached to the pyridine ring, which endows it with unique reactivity and potential applications in various fields.
Uses
Used in Organic Synthesis:
(5-Chloro-3-nitro-pyridin-2-yl)-hydrazine serves as a versatile building block in the synthesis of a wide range of organic compounds and pharmaceuticals. Its structural features allow it to participate in various organic reactions such as nucleophilic substitution, condensation, and reduction reactions, making it a valuable component in creating new molecules with desired properties.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (5-Chloro-3-nitro-pyridin-2-yl)-hydrazine is utilized as a key intermediate in the development of drugs with potential therapeutic applications. Its ability to engage in different types of chemical reactions facilitates the creation of novel drug candidates that can address unmet medical needs.
Used as a Pesticide:
(5-Chloro-3-nitro-pyridin-2-yl)-hydrazine has been studied for its potential as a pesticide due to its structural properties. Its reactivity and functional groups may contribute to the development of effective pesticides that can protect crops from pests and diseases, thereby increasing agricultural productivity.
Used as an Antimicrobial Agent:
Additionally, (5-Chloro-3-nitro-pyridin-2-yl)-hydrazine has been investigated for its potential as an antimicrobial agent. Its chemical structure may provide it with the ability to target and eliminate harmful microorganisms, offering a new avenue for the development of antimicrobial products to combat infections and maintain public health.
Check Digit Verification of cas no
The CAS Registry Mumber 22353-46-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,3,5 and 3 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 22353-46:
(7*2)+(6*2)+(5*3)+(4*5)+(3*3)+(2*4)+(1*6)=84
84 % 10 = 4
So 22353-46-4 is a valid CAS Registry Number.
22353-46-4Relevant articles and documents
As neuroprotective agents of pharmaceutical compounds
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Paragraph 0487; 0488; 0489; 0490, (2019/06/26)
The invention discloses a medicinal compound as a neuroprotective agent. The medicinal compound is a neuronal nitric oxide synthase-postsynaptic density protein 95 (nNOS-PSD95) decoupling agent. The medicinal compound is a benzene ring derivative shown in the general formula (I) or its pharmaceutically acceptable salt. The invention further discloses a preparation method of the medicinal compound and a use of the medicinal compound in prevention and treatment on neuronal damage influence-caused diseases.
Synthesis and evaluation of 8-amino-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives as glycogen synthase kinase-3 (GSK-3) inhibitors
Chun, Kwangwoo,Park, Ji-Seon,Lee, Han-Chang,Kim, Young-Ha,Ye, In-Hea,Kim, Kang-Jeon,Ku, Il-Whea,Noh, Min-Young,Cho, Goang-Won,Kim, Heejaung,Kim, Seung Hyun,Kim, Jeongmin
, p. 3983 - 3987 (2013/07/27)
New potent glycogen synthase kinase-3 (GSK-3) inhibitors, 8-amino-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one derivatives, were designed by modeling, synthesized and evaluated in vitro. Compound 17c showed good potency in enzyme and cell-based assays (IC50 = 111 nM, EC50 = 1.78 μM). Moreover, it has demonstrated desirable water solubility, PK profile, and moderate brain penetration.
